| Literature DB >> 29169950 |
Agnieszka Kamińska1, Francisco J Enguita2, Ewa Ł Stępień3.
Abstract
Lactadherin is a small (53-66kDa) multifunctional glycoprotein belonging to the secreted extracellular matrix protein family. It has a multi-domain structure and is involved in many biological and physiological processes, including phagocytosis, angiogenesis, atherosclerosis, tissue remodeling, and haemostasis regulation. Lactadherin binds phosphatidylserine (PS)-enriched cell surfaces in a receptor-independent manner. Interaction between lactadherin and PS is crucial for regulation of blood coagulation processes. This review summarizes recent knowledge on the possible role of lactadherin in haemostasis control, emphasizing the great significance of the interaction between lactadherin and PS expressed on activated platelets and extracellular vesicles. The possible role of lactadherin as a therapeutic target and biomarker is also discussed.Entities:
Keywords: Coagulation; MFG-E8; Microvesicles; Phosphatidylserine; RGD
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Year: 2017 PMID： 29169950 DOI： 10.1016/j.vph.2017.11.006
Source DB: PubMed Journal: Vascul Pharmacol ISSN： 1537-1891 Impact factor: 5.773