Literature DB >> 2916986

Increased levels of platelet-activating factor in blood following intestinal ischemia in the dog.

J Filep1, F Hermán, P Braquet, T Mózes.   

Abstract

The possible role of platelet-activating factor (PAF) in superior mesenteric artery occlusion induced circulatory collapse was studied in anesthetized dogs. PAF was measured by platelet aggregation assay. Identity of PAF-like product in blood was ascertained by thin layer chromatography, high pressure liquid chromatography and alkaline treatment. Low amount of PAF was detected in the mesenteric blood under normal conditions, during reperfusion PAF levels were significantly higher. Pretreatment of the animals with BN 52021, a specific PAF receptor antagonist abolished the fall in mean arterial pressure and the rise in hematocrit due to ischemia/reperfusion. These findings suggest that PAF may play an important role in mesenteric ischemia-induced circulatory collapse.

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Year:  1989        PMID： 2916986     DOI： 10.1016/s0006-291x(89)80055-5

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  15 in total

Review 1.  PAF. A review of its effects, antagonists and possible future clinical implications (Part II).

Authors:  M Koltai; D Hosford; P Guinot; A Esanu; P Braquet
Journal:  Drugs       Date:  1991-08       Impact factor: 9.546

Review 2.  Involvement of neutrophils in ischemia-reperfusion injury in the small intestine.

Authors:  H Arndt; P Kubes; D N Granger
Journal:  Klin Wochenschr       Date:  1991-12-15

3.  Effects of endothelin-1 on vascular permeability in the conscious rat: interactions with platelet-activating factor.

Authors:  J G Filep; M G Sirois; A Rousseau; A Fournier; P Sirois
Journal:  Br J Pharmacol       Date:  1991-12       Impact factor: 8.739

4.  Interaction of platelet-activating factor, spleen and atrial natriuretic peptide in plasma volume regulation during endotoxaemia in rats.

Authors:  X W Qu; R A Rozenfeld; W Huang; S E Crawford; F Gonzalez-Crussi; W Hsueh
Journal:  J Physiol       Date:  1998-10-01       Impact factor: 5.182

5.  Intravascular release of a platelet-activating factor-like lipid (PAF-LL) induced by cigarette smoking.

Authors:  T Imaizumi
Journal:  Lipids       Date:  1991-12       Impact factor: 1.880

6.  Modulation by nitric oxide of platelet-activating factor-induced albumin extravasation in the conscious rat.

Authors:  J G Filep; E Földes-Filep
Journal:  Br J Pharmacol       Date:  1993-12       Impact factor: 8.739

7.  Hypoxic induction of interleukin-8 gene expression in human endothelial cells.

Authors:  M Karakurum; R Shreeniwas; J Chen; D Pinsky; S D Yan; M Anderson; K Sunouchi; J Major; T Hamilton; K Kuwabara; A Rot; R Nowygrod; D Stern
Journal:  J Clin Invest       Date:  1994-04       Impact factor: 14.808

8.  Nitric oxide modulates vascular permeability in the rat coronary circulation.

Authors:  J G Filep; E Földes-Filep; P Sirois
Journal:  Br J Pharmacol       Date:  1993-02       Impact factor: 8.739

9.  Sequential release of tumour necrosis factor, platelet activating factor and eicosanoids during endotoxin shock in anaesthetized pigs: protective effects of indomethacin.

Authors:  T Mózes; F J Zijlstra; J P Heiligers; C J Tak; S Ben-Efraim; I L Bonta; P R Saxena
Journal:  Br J Pharmacol       Date:  1991-11       Impact factor: 8.739

10.  Dexamethasone-induced gastric mucosal damage in the rat: possible role of platelet-activating factor.

Authors:  J G Filep; F Hermán; E Földes-Filep; F Schneider; P Braquet
Journal:  Br J Pharmacol       Date:  1992-04       Impact factor: 8.739
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