Literature DB >> 29169462

Skin-Derived Vitamin D3 Protects against Basal Cell Carcinoma.

Maarten F Bijlsma1, Henk Roelink2.   

Abstract

UVR in sunlight causes mutations that drive basal cell carcinomas. However, the incidence of these tumors plateaus with prolonged exposure, but the incidence of other skin cancers increases. Makarova et al. now show that vitamin D3 produced in the skin by UVR protects against its oncogenic effects by inhibiting Hedgehog signaling, whereas dietary vitamin D3 does not.
Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

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Year:  2017        PMID： 29169462      PMCID： PMC6154801          DOI： 10.1016/j.jid.2017.07.816

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   8.551


  10 in total

1.  Vitamin D3 Produced by Skin Exposure to UVR Inhibits Murine Basal Cell Carcinoma Carcinogenesis.

Authors:  Anastasia Makarova; Grace Wang; John A Dolorito; Subheksha Kc; Eileen Libove; Ervin H Epstein
Journal:  J Invest Dermatol       Date:  2017-07-31       Impact factor: 8.551

2.  Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice.

Authors:  M Aszterbaum; J Epstein; A Oro; V Douglas; P E LeBoit; M P Scott; E H Epstein
Journal:  Nat Med       Date:  1999-11       Impact factor: 53.440

3.  A Functional and Putative Physiological Role of Calcitriol in Patched1/Smoothened Interaction.

Authors:  Benedikt Linder; Susanne Weber; Kai Dittmann; Jerzy Adamski; Heidi Hahn; Anja Uhmann
Journal:  J Biol Chem       Date:  2015-06-30       Impact factor: 5.157

4.  Vitamin D3 inhibits hedgehog signaling and proliferation in murine Basal cell carcinomas.

Authors:  Jean Y Tang; Tony Zheng Xiao; Yuko Oda; Kris S Chang; Elana Shpall; Angela Wu; Po-Lin So; Jennifer Hebert; Daniel Bikle; Ervin H Epstein
Journal:  Cancer Prev Res (Phila)       Date:  2011-03-24

5.  Activating Smoothened mutations in sporadic basal-cell carcinoma.

Authors:  J Xie; M Murone; S M Luoh; A Ryan; Q Gu; C Zhang; J M Bonifas; C W Lam; M Hynes; A Goddard; A Rosenthal; E H Epstein; F J de Sauvage
Journal:  Nature       Date:  1998-01-01       Impact factor: 49.962

6.  Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome.

Authors:  H Hahn; C Wicking; P G Zaphiropoulous; M R Gailani; S Shanley; A Chidambaram; I Vorechovsky; E Holmberg; A B Unden; S Gillies; K Negus; I Smyth; C Pressman; D J Leffell; B Gerrard; A M Goldstein; M Dean; R Toftgard; G Chenevix-Trench; B Wainwright; A E Bale
Journal:  Cell       Date:  1996-06-14       Impact factor: 41.582

7.  Patched acts catalytically to suppress the activity of Smoothened.

Authors:  J Taipale; M K Cooper; T Maiti; P A Beachy
Journal:  Nature       Date:  2002-08-22       Impact factor: 49.962

8.  Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion.

Authors:  Maarten F Bijlsma; C Arnold Spek; Danica Zivkovic; Sandra van de Water; Farhad Rezaee; Maikel P Peppelenbosch
Journal:  PLoS Biol       Date:  2006-07       Impact factor: 8.029

9.  Patched1 and Patched2 inhibit Smoothened non-cell autonomously.

Authors:  Brock Roberts; Catalina Casillas; Astrid C Alfaro; Carina Jägers; Henk Roelink
Journal:  Elife       Date:  2016-08-23       Impact factor: 8.140

10.  The multicentre south European study 'Helios'. II: Different sun exposure patterns in the aetiology of basal cell and squamous cell carcinomas of the skin.

Authors:  S Rosso; R Zanetti; C Martinez; M J Tormo; S Schraub; H Sancho-Garnier; S Franceschi; L Gafà; E Perea; C Navarro; R Laurent; C Schrameck; R Talamini; R Tumino; J Wechsler
Journal:  Br J Cancer       Date:  1996-06       Impact factor: 7.640
  10 in total
  2 in total

Review 1.  Sex disparity in skin carcinogenesis and potential influence of sex hormones.

Authors:  V Collier; M Musicante; T Patel; F Liu-Smith
Journal:  Skin Health Dis       Date:  2021-04-01

2.  Increased integrity of cell-cell junctions accompanied by increased expression of claudin 4 in keratinocytes stimulated with vitamin D3.

Authors:  Erika Minowa; Yoshihito Kurashige; Syed Taufiqul Islam; Koki Yoshida; Sayaka Sakakibara; Yunosuke Okada; Yusuke Fujita; Dembereldorj Bolortsetseg; Yuji Murai; Yoshihiro Abiko; Masato Saitoh
Journal:  Med Mol Morphol       Date:  2021-07-29       Impact factor: 2.309
  2 in total

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