Zhiyue Liu1, Alan G Nyitray1,2, Lu-Yu Hwang1,2, Michael D Swartz3, Martha Abrahamsen4, Eduardo Lazcano-Ponce5, Luisa L Villa6, Anna R Giuliano4. 1. Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center, Houston. 2. Center for Infectious Diseases, University of Texas Health Science Center, Houston. 3. Department of Biostatistics, School of Public Health, University of Texas Health Science Center, Houston. 4. Center for Infection Research in Cancer, Moffitt Cancer Center and Research Institute, Tampa, Florida. 5. Instituto Nacional de Salud Pública, Cuernavaca, México. 6. Faculdade de Medicina, Universidade de São Paulo Department of Radiology and Oncology, Centro de Investigação Translacional em Oncologia, Instituto do Câncer do Estado de São Paulo, Brazil.
Abstract
Background: Little is known about the natural history of human papillomavirus (HPV) infection in male virgins. This study estimated the incidence and clearance of genital HPV infection and the factors associated with these measures among men who denied at baseline ever having penetrative sex. Methods: A cohort of 4123 men residing in Brazil, Mexico, and the United States were followed every 6 months for up to 10 visits. Genital exfoliated cells were collected and genotyped for 36 HPV types. Eighty-seven men were classified as virgins and included for analysis. Cox proportional hazards models identified factors associated with the incidence and clearance of genital HPV infection. Results: The incidence rates for any HPV infection among virgins who did and those who did not initiate sex during follow-up were 26.2 and 14.6 cases/1000 person-months, respectively. After penetrative sex initiation, 45.5% of men acquired HPV within 24 months. Younger age, current smoking, no recent female sex partners, and prevalent HPV infection were associated with high-risk HPV clearance. Conclusion: Virgins who did not initiate sex during follow-up still acquired HPV infection, possibly through nonpenetrative sexual contact. Further prospective cohort studies are needed to better understand factors associated with HPV acquisition and clearance in male virgins and recent nonvirgins.
Background: Little is known about the natural history of human papillomavirus (HPV) infection in male virgins. This study estimated the incidence and clearance of genital HPV infection and the factors associated with these measures among men who denied at baseline ever having penetrative sex. Methods: A cohort of 4123 men residing in Brazil, Mexico, and the United States were followed every 6 months for up to 10 visits. Genital exfoliated cells were collected and genotyped for 36 HPV types. Eighty-seven men were classified as virgins and included for analysis. Cox proportional hazards models identified factors associated with the incidence and clearance of genital HPV infection. Results: The incidence rates for any HPV infection among virgins who did and those who did not initiate sex during follow-up were 26.2 and 14.6 cases/1000 person-months, respectively. After penetrative sex initiation, 45.5% of men acquired HPV within 24 months. Younger age, current smoking, no recent female sex partners, and prevalent HPV infection were associated with high-risk HPV clearance. Conclusion: Virgins who did not initiate sex during follow-up still acquired HPV infection, possibly through nonpenetrative sexual contact. Further prospective cohort studies are needed to better understand factors associated with HPV acquisition and clearance in male virgins and recent nonvirgins.
Authors: P E Gravitt; C L Peyton; T Q Alessi; C M Wheeler; F Coutlée; A Hildesheim; M H Schiffman; D R Scott; R J Apple Journal: J Clin Microbiol Date: 2000-01 Impact factor: 5.948
Authors: Shitaldas J Pamnani; Staci L Sudenga; Raphael Viscidi; Dana E Rollison; B Nelson Torres; Donna J Ingles; Martha Abrahamsen; Luisa L Villa; Eduardo Lazcano-Ponce; Jorge Salmeron; Manuel Quiterio; Yangxin Huang; Amy Borenstein; Anna R Giuliano Journal: Cancer Res Date: 2016-08-17 Impact factor: 12.701
Authors: Anna R Giuliano; Eduardo Lazcano-Ponce; Luisa L Villa; Roberto Flores; Jorge Salmeron; Ji-Hyun Lee; Mary R Papenfuss; Martha Abrahamsen; Emily Jolles; Carrie M Nielson; Maria Luisa Baggio; Roberto Silva; Manuel Quiterio Journal: Cancer Epidemiol Biomarkers Prev Date: 2008-08 Impact factor: 4.254
Authors: John Doorbar; Wim Quint; Lawrence Banks; Ignacio G Bravo; Mark Stoler; Tom R Broker; Margaret A Stanley Journal: Vaccine Date: 2012-11-20 Impact factor: 3.641
Authors: Kathleen B Cartmell; Carlie R Mzik; Beth L Sundstrom; John S Luque; Ashley White; Jennifer Young-Pierce Journal: J Cancer Educ Date: 2019-10 Impact factor: 2.037
Authors: Mahmoud H Mosli; Marwan Albeshri; Mohammad N Alsanea; Turki AlAmeel; Haneen Alabsi; Majid Alsahafi; Omar Saadah; Yousef Qari Journal: J Family Med Prim Care Date: 2022-05-14
Authors: Lea E Widdice; David I Bernstein; Eduardo L Franco; Lili Ding; Darron R Brown; Aaron C Ermel; Lisa Higgins; Jessica A Kahn Journal: Vaccine Date: 2019-09-30 Impact factor: 3.641
Authors: Manar Mousa; Sawsan S Al-Amri; Afnan A Degnah; Ahmed M Tolah; Hanin H Abduljabbar; Ayman M Oraif; Hassan S Abduljabbar; Ahmed A Mirza; Esam I Azhar; Anwar M Hashem Journal: Ann Saudi Med Date: 2019-12-05 Impact factor: 1.526
Authors: Evy Yunihastuti; Nipat Teeratakulpisarn; Wifanto Saditya Jeo; Hanny Nilasari; Lisnawati Rachmadi; I Ketut Agus Somia; Made Dewi Dian Sukmawati; Komang Agus Trisna Amijaya; Ilias A Yee; Nany Hairunisa; Piranun Hongchookiat; Deondara Trachunthong; Tippawan Pankam; Siriporn Nonenoy; Reshmie Ramautarsing; Iskandar Azwa; Tuti P Merati; Praphan Phanuphak; Nittaya Phanuphak; Joel M Palefsky Journal: AIDS Date: 2020-11-01 Impact factor: 4.632