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Literature DB >> 29164885

Inducing Protein Degradation as a Therapeutic Strategy.

Craig M Crews.

Abstract

Mesh：

Year: 2017 PMID： 29164885 DOI： 10.1021/acs.jmedchem.7b01333

Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446

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11 in total

1. The Evolving Druggability and Developability Space: Chemically Modified New Modalities and Emerging Small Molecules.

Authors: Wenzhan Yang; Prajakta Gadgil; Venkata R Krishnamurthy; Margaret Landis; Pankajini Mallick; Dipal Patel; Phenil J Patel; Darren L Reid; Manuel Sanchez-Felix
Journal: AAPS J Date: 2020-01-03 Impact factor: 4.009

2. Kinetic Detection of E3:PROTAC:Target Ternary Complexes Using NanoBRET Technology in Live Cells.

Authors: Sarah D Mahan; Kristin M Riching; Marjeta Urh; Danette L Daniels
Journal: Methods Mol Biol Date: 2021

Review 3. Cure and Long-Term Remission Strategies.

Authors: Luisa Mori; Susana T Valente
Journal: Methods Mol Biol Date: 2022

4. PROTACs technology for treatment of Alzheimer's disease: Advances and perspectives.

Authors: Hiroyuki Inuzuka; Jing Liu; Wenyi Wei; Abdol-Hossein Rezaeian
Journal: Acta Mater Med Date: 2022-01-21

Review 5. Bromodomain and BET family proteins as epigenetic targets in cancer therapy: their degradation, present drugs, and possible PROTACs.

Authors: Mohd Muddassir; Kunjal Soni; Chetan B Sangani; Abdullah Alarifi; Mohd Afzal; Naaser A Y Abduh; Yongtao Duan; Poonam Bhadja
Journal: RSC Adv Date: 2020-12-24 Impact factor: 4.036

Inducing Protein Degradation as a Therapeutic Strategy.

1. The Evolving Druggability and Developability Space: Chemically Modified New Modalities and Emerging Small Molecules.

2. Kinetic Detection of E3:PROTAC:Target Ternary Complexes Using NanoBRET Technology in Live Cells.

Review 3. Cure and Long-Term Remission Strategies.

4. PROTACs technology for treatment of Alzheimer's disease: Advances and perspectives.

Review 5. Bromodomain and BET family proteins as epigenetic targets in cancer therapy: their degradation, present drugs, and possible PROTACs.

6. Pyrazol-1-yl-propanamides as SARD and Pan-Antagonists for the Treatment of Enzalutamide-Resistant Prostate Cancer.

Review 7. Targeting RNA structures with small molecules.

8. Homo-PROTAC mediated suicide of MDM2 to treat non-small cell lung cancer.

Review 9. Small Molecule Modulators of RING-Type E3 Ligases: MDM and Cullin Families as Targets.

Review 10. The PROTAC technology in drug development.