| Literature DB >> 29162520 |
Maite Ruiz-Goikoetxea1, Samuele Cortese2, Maite Aznarez-Sanado3, Sara Magallón4, Noelia Alvarez Zallo5, Elkin O Luis6, Pilar de Castro-Manglano7, Cesar Soutullo8, Gonzalo Arrondo9.
Abstract
A systematic review with meta-analyses was performed to: 1) quantify the association between ADHD and risk of unintentional physical injuries in children/adolescents ("risk analysis"); 2) assess the effect of ADHD medications on this risk ("medication analysis"). We searched 114 databases through June 2017. For the risk analysis, studies reporting sex-controlled odds ratios (ORs) or hazard ratios (HRs) estimating the association between ADHD and injuries were combined. Pooled ORs (28 studies, 4,055,620 individuals without and 350,938 with ADHD) and HRs (4 studies, 901,891 individuals without and 20,363 with ADHD) were 1.53 (95% CI=1.40,1.67) and 1.39 (95% CI=1.06,1.83), respectively. For the medication analysis, we meta-analysed studies that avoided the confounding-by-indication bias [four studies with a self-controlled methodology and another comparing risk over time and groups (a "difference in differences" methodology)]. The pooled effect size was 0.879 (95% CI=0.838,0.922) (13,254 individuals with ADHD). ADHD is significantly associated with an increased risk of unintentional injuries and ADHD medications have a protective effect, at least in the short term, as indicated by self-controlled studies.Entities:
Keywords: ADHD; Child psychiatry; Epidemiology; Pediatrics; Public health; Robust variance estimation; Stimulants; Unintentional physical injuries
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Year: 2017 PMID： 29162520 DOI： 10.1016/j.neubiorev.2017.11.007
Source DB: PubMed Journal: Neurosci Biobehav Rev ISSN： 0149-7634 Impact factor: 8.989