Literature DB >> 29162457

Antiplasmodial alkaloids from bulbs of Amaryllis belladonna Steud.

Namki Cho1, Yongle Du1, Ana Lisa Valenciano2, Maria L Fernández-Murga3, Michael Goetz4, Jason Clement4, Maria B Cassera2, David G I Kingston5.   

Abstract

A bioassay-guided fractionation and chemical investigation of Amaryllis belladonna Steud. bulbs resulted in the isolation and identification of the new crinane alkaloid 1,4-dihydroxy-3-methoxy powellan (1), along with the 3 known crinane alkaloids 2-4 and the two lycorane alkaloids 5-6. The structures were elucidated by interpretation of combined HR-ESIMS, CD and 2D NMR spectroscopic data. Among these isolated compounds the lycorane-type alkaloid acetylcaranine (5) exhibited strong antiplasmodial activity, while compounds 3 and 4 were moderately active, and compounds 1 and 6 were inactive.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Amaryllis belladonna; Antiplasmodial; Bioassay-guided; Crinane; Lycorine

Mesh：

Substances：

Year:  2017        PMID： 29162457      PMCID： PMC5753767          DOI： 10.1016/j.bmcl.2017.11.021

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


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