Literature DB >> 29161564

Cell Biology: When Your Own Chromosomes Act like Foreign DNA.

Alexander Spektor1, Neil T Umbreit2, David Pellman3.   

Abstract

Two recent papers report the activation of a pro-inflammatory response by cytoplasmic DNA from aberrant nuclear structures called micronuclei. The findings have implications for tumor immunity, immunotherapy biomarker discovery, and possibly the many-sided effects of senescence-associated secretory phenotype.
Copyright © 2017 Elsevier Ltd. All rights reserved.

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Year:  2017        PMID: 29161564     DOI: 10.1016/j.cub.2017.09.043

Source DB:  PubMed          Journal:  Curr Biol        ISSN: 0960-9822            Impact factor:   10.834


  5 in total

1.  The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death.

Authors:  Christian Zierhut; Norihiro Yamaguchi; Maria Paredes; Ji-Dung Luo; Thomas Carroll; Hironori Funabiki
Journal:  Cell       Date:  2019-07-11       Impact factor: 41.582

Review 2.  Functional mechanisms and abnormalities of the nuclear lamina.

Authors:  Adam Karoutas; Asifa Akhtar
Journal:  Nat Cell Biol       Date:  2021-02-08       Impact factor: 28.824

Review 3.  Cytokinesis-Block Micronucleus Cytome Assay Evolution into a More Comprehensive Method to Measure Chromosomal Instability.

Authors:  Michael Fenech
Journal:  Genes (Basel)       Date:  2020-10-15       Impact factor: 4.096

Review 4.  Inflammatory cytokine storms severity may be fueled by interactions of micronuclei and RNA viruses such as COVID-19 virus SARS-CoV-2. A hypothesis.

Authors:  Micheline Kirsch-Volders; Michael Fenech
Journal:  Mutat Res Rev Mutat Res       Date:  2021-09-28       Impact factor: 5.657

5.  Factors promoting nuclear envelope assembly independent of the canonical ESCRT pathway.

Authors:  I-Ju Lee; Ema Stokasimov; Nathaniel Dempsey; Joseph M Varberg; Etai Jacob; Sue L Jaspersen; David Pellman
Journal:  J Cell Biol       Date:  2020-06-01       Impact factor: 10.539

  5 in total

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