Literature DB >> 2916128

Overexpression of transforming growth factor alpha in psoriatic epidermis.

J T Elder1, G J Fisher, P B Lindquist, G L Bennett, M R Pittelkow, R J Coffey, L Ellingsworth, R Derynck, J J Voorhees.   

Abstract

Transforming growth factor alpha (TGF-alpha) is produced by and required for the growth of epithelial cells and is angiogenic in vivo. Since epidermal hyperplasia and angiogenesis are hallmarks of psoriasis, TGF-alpha gene expression was analyzed in epidermal biopsies of normal and psoriatic skin. TGF-alpha messenger RNA and protein are much more abundant in lesional psoriatic epidermis than in normal-appearing skin of psoriatic patients or in normal epidermis. In contrast, messenger RNA levels of transforming growth factor beta 1 (TGF-beta 1), which inhibits epithelial cell growth, are not significantly different in normal, uninvolved, and lesional psoriatic epidermis. Thus, psoriatic epidermal hyperplasia may involve increased expression of a keratinocyte mitogen (TGF-alpha) rather than deficient expression of a growth inhibitor (TGF-beta 1).

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Year:  1989        PMID： 2916128     DOI： 10.1126/science.2916128

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  97 in total

1.  Heparin-binding ligands mediate autocrine epidermal growth factor receptor activation In skin organ culture.

Authors:  S Stoll; W Garner; J Elder
Journal:  J Clin Invest       Date:  1997-09-01       Impact factor: 14.808

2.  Matrix-independent survival of human keratinocytes through an EGF receptor/MAPK-kinase-dependent pathway.

Authors:  M Jost; T M Huggett; C Kari; U Rodeck
Journal:  Mol Biol Cell       Date:  2001-05       Impact factor: 4.138

3.  Expression of transforming growth factor alpha in human tissues: immunohistochemical study and northern blot analysis.

Authors:  W Yasui; Z Q Ji; H Kuniyasu; A Ayhan; H Yokozaki; H Ito; E Tahara
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1992

Review 4.  Immunological mechanisms involved in psoriasis.

Authors:  C E Griffiths; J J Voorhees
Journal:  Springer Semin Immunopathol       Date:  1992

Review 5.  Molecular targeting of angiogenesis for imaging and therapy.

Authors:  Simon S Brack; Ludger M Dinkelborg; Dario Neri
Journal:  Eur J Nucl Med Mol Imaging       Date:  2004-08-05       Impact factor: 9.236

6.  Expression, topography, and function of integrin receptors are severely altered in keratinocytes from involved and uninvolved psoriatic skin.

Authors:  G Pellegrini; M De Luca; G Orecchia; F Balzac; O Cremona; P Savoia; R Cancedda; P C Marchisio
Journal:  J Clin Invest       Date:  1992-06       Impact factor: 14.808

Review 7.  Tyrosine kinases in inflammatory dermatologic disease.

Authors:  Ricardo T Paniagua; David F Fiorentino; Lorinda Chung; William H Robinson
Journal:  J Am Acad Dermatol       Date:  2010-06-26       Impact factor: 11.527

8.  Targeted expression of the E6 and E7 oncogenes of human papillomavirus type 16 in the epidermis of transgenic mice elicits generalized epidermal hyperplasia involving autocrine factors.

Authors:  P Auewarakul; L Gissmann; A Cid-Arregui
Journal:  Mol Cell Biol       Date:  1994-12       Impact factor: 4.272

9.  Increased epidermal cell proliferation in normal human skin in vivo following local administration of interferon-gamma.

Authors:  J N Barker; J R Goodlad; E L Ross; C C Yu; R W Groves; D M MacDonald
Journal:  Am J Pathol       Date:  1993-04       Impact factor: 4.307

10.  Epidermal growth factor and transforming growth factor alpha specifically induce the activation- and hyperproliferation-associated keratins 6 and 16.

Authors:  C K Jiang; T Magnaldo; M Ohtsuki; I M Freedberg; F Bernerd; M Blumenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-15       Impact factor: 11.205
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