Andrea Govetto1,2, Gianni Virgili3, Francisco J Rodriguez2, Marta S Figueroa4, David Sarraf5, Jean Pierre Hubschman1. 1. Retina Division, Stein Eye Institute, University of California, Los Angeles, Los Angeles, California. 2. Ophthalmology Unit, Fatebenefratelli and Oftalmico Hospital, ASST Fatebenefratelli Sacco, Milan, Italy. 3. Ophthalmology Department, Careggi University Hospital, Florence, Italy. 4. Retina Division, Ramon y Cajal University Hospital, Madrid, Spain. 5. Retinal Disorders and Ophthalmic Genetics Division, Stein Eye Institute, University of California, Los Angeles, Los Angeles, California.
Abstract
PURPOSE: To describe the functional and anatomical outcomes of pars plana vitrectomy with epiretinal membrane and internal limiting membrane peel in eyes with and without ectopic inner foveal layers (EIFLs). METHODS: In this retrospective multicenter study, patients diagnosed with idiopathic epiretinal membranes who underwent pars plana vitrectomy with epiretinal membrane and internal limiting membrane peel were enrolled, with a minimum follow-up of 12 months. Preoperative and postoperative spectral domain optical coherence tomography scans were qualitatively and quantitatively evaluated. The association of the EIFL and other spectral domain optical coherence tomography parameters with preoperative and postoperative best-corrected visual acuity (BCVA) was analyzed. RESULTS: One hundred eleven eyes of 107 patients were included. Preoperatively, the EIFLs were present in 56 of 111 eyes (50.4%). The presence of EIFL was significantly associated with lower preoperative and postoperative BCVA (P < 0.001). Ectopic inner foveal layer thickness was negatively correlated with preoperative BCVA (r = 0.58, P < 0.001). Postoperatively, the EIFL persisted in 51 of 56 eyes (91%) with Stage 3 and 4 epiretinal membranes. Ectopic inner foveal layer thickness decreased significantly after surgery (P < 0.001), but postoperative EIFL thinning had no direct effect on postoperative change in BCVA. At 12 months from surgery, EIFL thickness maintained a significant negative correlation with BCVA (r = 0.55, P < 0.001). CONCLUSION: The presence of EIFL should be considered a negative prognostic factor for postoperative anatomical and functional recovery.
PURPOSE: To describe the functional and anatomical outcomes of pars plana vitrectomy with epiretinal membrane and internal limiting membrane peel in eyes with and without ectopic inner foveal layers (EIFLs). METHODS: In this retrospective multicenter study, patients diagnosed with idiopathic epiretinal membranes who underwent pars plana vitrectomy with epiretinal membrane and internal limiting membrane peel were enrolled, with a minimum follow-up of 12 months. Preoperative and postoperative spectral domain optical coherence tomography scans were qualitatively and quantitatively evaluated. The association of the EIFL and other spectral domain optical coherence tomography parameters with preoperative and postoperative best-corrected visual acuity (BCVA) was analyzed. RESULTS: One hundred eleven eyes of 107 patients were included. Preoperatively, the EIFLs were present in 56 of 111 eyes (50.4%). The presence of EIFL was significantly associated with lower preoperative and postoperative BCVA (P < 0.001). Ectopic inner foveal layer thickness was negatively correlated with preoperative BCVA (r = 0.58, P < 0.001). Postoperatively, the EIFL persisted in 51 of 56 eyes (91%) with Stage 3 and 4 epiretinal membranes. Ectopic inner foveal layer thickness decreased significantly after surgery (P < 0.001), but postoperative EIFL thinning had no direct effect on postoperative change in BCVA. At 12 months from surgery, EIFL thickness maintained a significant negative correlation with BCVA (r = 0.55, P < 0.001). CONCLUSION: The presence of EIFL should be considered a negative prognostic factor for postoperative anatomical and functional recovery.
Authors: Michele Coppola; Maria Brambati; Maria Vittoria Cicinelli; Alessandro Marchese; Emma Clara Zanzottera; Antonio Peroglio Deiro; Michal Post; Francesco Bandello Journal: Graefes Arch Clin Exp Ophthalmol Date: 2021-02-02 Impact factor: 3.117
Authors: Mario R Romano; Gennaro Ilardi; Mariantonia Ferrara; Gilda Cennamo; Davide Allegrini; Pia Clara Pafundi; Ciro Costagliola; Stefania Staibano; Giovanni Cennamo Journal: PLoS One Date: 2018-05-08 Impact factor: 3.240
Authors: Lorenzo Iuliano; Gloria Cisa di Gresy; Giovanni Fogliato; Eleonora Corbelli; Francesco Bandello; Marco Codenotti Journal: Eye Vis (Lond) Date: 2021-08-04