Literature DB >> 29160059

Deuterated Drug Molecules: Focus on FDA-Approved DeutetrabenazinePublished as part of the Biochemistry series "Biochemistry to Bedside".

Sheila H DeWitt1, Bruce E Maryanoff2,3.   

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Year:  2017        PMID: 29160059     DOI: 10.1021/acs.biochem.7b00765

Source DB:  PubMed          Journal:  Biochemistry        ISSN: 0006-2960            Impact factor:   3.162


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  12 in total

1.  Trideuteromethylation Enabled by a Sulfoxonium Metathesis Reaction.

Authors:  Zuyuan Shen; Shilei Zhang; Huihui Geng; Jiarui Wang; Xinyu Zhang; Anqi Zhou; Cheng Yao; Xiaobei Chen; Wei Wang
Journal:  Org Lett       Date:  2019-01-07       Impact factor: 6.005

2.  deutetrabenazine for the treatment of chorea associated with Huntington's disease.

Authors:  Harshit Gupta; Wil Perkins; Cain Stark; Sathya Kikkeri; Juyeon Kakazu; Adam Kaye; Alan Kaye
Journal:  Health Psychol Res       Date:  2022-06-28

3.  C(sp2)-H Activation with Bis(silylene)pyridine Cobalt(III) Complexes: Catalytic Hydrogen Isotope Exchange of Sterically-Hindered C-H Bonds.

Authors:  Jose B Roque; Tyler P Pabst; Paul J Chirik
Journal:  ACS Catal       Date:  2022-07-11       Impact factor: 13.700

4.  Rational deuteration of dronedarone attenuates its toxicity in human hepatic HepG2 cells.

Authors:  Lloyd Wei Tat Tang; Royden Yu Ren Lim; Gopalakrishnan Venkatesan; Eric Chun Yong Chan
Journal:  Toxicol Res (Camb)       Date:  2022-03-28       Impact factor: 2.680

5.  Deuteration of the farnesyl terminal methyl groups of δ-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production.

Authors:  Xingui Liu; Zhengya Gao; Qiang Fu; Lin Song; Peiyi Zhang; Xuan Zhang; Howard Hendrickson; Peter A Crooks; Daohong Zhou; Guangrong Zheng
Journal:  Bioorg Med Chem       Date:  2020-04-08       Impact factor: 3.641

Review 6.  VMAT2 Inhibitors in Neuropsychiatric Disorders.

Authors:  Arjun Tarakad; Joohi Jimenez-Shahed
Journal:  CNS Drugs       Date:  2018-12       Impact factor: 5.749

7.  Production of deuterated biomass by cultivation of Lemna minor (duckweed) in D2O.

Authors:  Barbara R Evans; Marcus Foston; Hugh M O'Neill; David Reeves; Caroline Rempe; Kathi McGrath; Arthur J Ragauskas; Brian H Davison
Journal:  Planta       Date:  2019-01-29       Impact factor: 4.116

8.  Relevance of Hydrogen Bonds for the Histamine H2 Receptor-Ligand Interactions: A Lesson from Deuteration.

Authors:  Mojca Kržan; Jan Keuschler; Janez Mavri; Robert Vianello
Journal:  Biomolecules       Date:  2020-01-29

9.  Safety and Pharmacokinetics of High-Dose TAS-303 in Healthy Japanese Volunteers: A Single-Center, Single-Blind, Randomized, Placebo-Controlled, Parallel-Group, Multiple-Ascending-Dose Study.

Authors:  Ryuzo Hanada
Journal:  Clin Pharmacol Drug Dev       Date:  2020-06-23

10.  Unexpected Substituent Effects in Spiro-Compound Formation: Steering N-Aryl Propynamides and DMSO toward Site-Specific Sulfination in Quinolin-2-ones or Spiro[4,5]trienones.

Authors:  Xiaoxian Li; Yuanxun Wang; Yaxin Ouyang; Zhenyang Yu; Beibei Zhang; Jingran Zhang; Haofeng Shi; Han Zuilhof; Yunfei Du
Journal:  J Org Chem       Date:  2021-06-29       Impact factor: 4.354

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