Elisabetta Costantini1, Ester Illiano1, Konstantinos Giannitsas2, Marco Prestipino3, Antonio Luigi Pastore4, Antonio Carbone4, Giovanni Palleschi4, Raffaele Balsamo5, Franca Natale6, Donata Villari7, Vittorio Bini8, Serena Maruccia9, Maria-Teresa Filocamo10, Alessandro Zucchi1. 1. Department of Surgical and Biomedical Sciences, Urology and Andrology Clinic, University of Perugia, Perugia, Italy. 2. Department of Urology, University of Patras School of Medicine, Patras University Hospital, Patras, Greece. 3. Department of Paediatric Surgery, C.U. Paediatric Surgery, University of Perugia, Perugia, Italy. 4. Department of Medico Surgical Sciences and Biotechnologies, Urology Unit, Sapienza University, ICOT, Rome, Italy. 5. Department of Urology, Magna Graecia University of Catanzaro, Catanzaro, Italy. 6. Department of Obstetrics and Gynecology, S. Carlo-IDI Hospital, Rome, Italy. 7. Department of Urology, University of Florence, Florence, Italy. 8. Internal Medicine, University of Perugia, Perugia, Italy. 9. Istituti Clinici Zucchi, Brughiero, Italy. 10. Department of Urology, Azienda Sanitaria Locale Cn1, Savigliano, Italy.
Abstract
OBJECTIVE: To investigate the correlation of a history of lower urinary tract symptomatology during childhood with lower urinary tract dysfunction in young adult women. SUBJECTS AND METHODS: This was a multicentre, prospective, case-control study conducted between April 2013 and November 2015. A total of 300 women, aged 18-40 years, participated. The case group comprised women attending urogynaecology clinics for various lower urinary tract complaints and the control group was recruited from a healthy population. Exclusion criteria were designed to avoid common causes of lower urinary tract dysfunction and symptoms and included diabetes mellitus, neurological disease and pelvic inflammatory disease. All women completed a self-administered 77-item questionnaire, exploring childhood urological and bowel history, as well as current urological, bowel and sexual symptoms. Statistical analysis was performed using chi-squared and Fisher's exact tests to compare categorical variables. Multivariate logistic regression models were fit for the prediction of the adult outcomes, incorporating as explanatory variables all those that showed a significant P value in bivariate analysis. P values < 0.05 were considered statistically significant. RESULTS: Women with childhood urinary voiding and storage symptoms had a higher prevalence of these symptoms in adult life compared with women without such history. Women with urinary tract infections (UTIs) during childhood had a higher incidence of adult UTIs compared with women without this problem in childhood. CONCLUSIONS: Lower urinary tract dysfunction in childhood seems to 'persist' in young adult life but the implications of this finding in clinical practice need to be defined in future studies.
OBJECTIVE: To investigate the correlation of a history of lower urinary tract symptomatology during childhood with lower urinary tract dysfunction in young adult women. SUBJECTS AND METHODS: This was a multicentre, prospective, case-control study conducted between April 2013 and November 2015. A total of 300 women, aged 18-40 years, participated. The case group comprised women attending urogynaecology clinics for various lower urinary tract complaints and the control group was recruited from a healthy population. Exclusion criteria were designed to avoid common causes of lower urinary tract dysfunction and symptoms and included diabetes mellitus, neurological disease and pelvic inflammatory disease. All women completed a self-administered 77-item questionnaire, exploring childhood urological and bowel history, as well as current urological, bowel and sexual symptoms. Statistical analysis was performed using chi-squared and Fisher's exact tests to compare categorical variables. Multivariate logistic regression models were fit for the prediction of the adult outcomes, incorporating as explanatory variables all those that showed a significant P value in bivariate analysis. P values < 0.05 were considered statistically significant. RESULTS:Women with childhood urinary voiding and storage symptoms had a higher prevalence of these symptoms in adult life compared with women without such history. Women with urinary tract infections (UTIs) during childhood had a higher incidence of adult UTIs compared with women without this problem in childhood. CONCLUSIONS: Lower urinary tract dysfunction in childhood seems to 'persist' in young adult life but the implications of this finding in clinical practice need to be defined in future studies.
Authors: Sonya S Brady; Amanda Berry; Deepa R Camenga; Colleen M Fitzgerald; Sheila Gahagan; Cecilia T Hardacker; Bernard L Harlow; Jeni Hebert-Beirne; D Yvette LaCoursiere; Jessica B Lewis; Lisa K Low; Jerry L Lowder; Alayne D Markland; Gerald McGwin; Diane K Newman; Mary H Palmer; David A Shoham; Ariana L Smith; Ann Stapleton; Beverly R Williams; Siobhan Sutcliffe Journal: Neurourol Urodyn Date: 2020-03-02 Impact factor: 2.696
Authors: Nao Iguchi; Alonso Carrasco; Alison X Xie; Ricardo H Pineda; Anna P Malykhina; Duncan T Wilcox Journal: Sci Rep Date: 2021-01-13 Impact factor: 4.379