Literature DB >> 29159998

Summary of the first inaugural joint meeting of the International Consortium for scoliosis genetics and the International Consortium for vertebral anomalies and scoliosis, March 16-18, 2017, Dallas, Texas.

Philip F Giampietro1, Olivier Pourquie2, Cathy Raggio3, Shiro Ikegawa4, Peter D Turnpenny5, Ryan Gray6, Sally L Dunwoodie7, Christina A Gurnett8, Benjamin Alman9, Kenneth Cheung10, Kenro Kusumi11, Nancy Hadley-Miller12, Carol A Wise13,14.   

Abstract

Scoliosis represents the most common musculoskeletal disorder in children and affects approximately 3% of the world population. Scoliosis is separated into two major phenotypic classifications: congenital and idiopathic. Idiopathic scoliosis is defined as a curvature of the spine of 10° or greater visualized on plane radiograph and does not have associated vertebral malformations (VM). "Congenital" scoliosis (CS) due to malformations in vertebrae is frequently associated with other birth defects. Recently, significant advances have been made in understanding the genetic basis of both conditions. There is evidence that both conditions are etiologically related. A 2-day conference entitled "Genomic Approaches to Understanding and Treating Scoliosis" was held at Scottish Rite Hospital for Children in Dallas, Texas, to synergize research in this field. This first combined, multidisciplinary conference featured international scoliosis researchers in basic and clinical sciences. A major outcome of the conference advancing scoliosis research was the proposal and subsequent vote in favor of merging the International Consortium for Vertebral Anomalies and Scoliosis (ICVAS) and International Consortium for Scoliosis Genetics (ICSG) into a single entity called International Consortium for Spinal Genetics, Development, and Disease (ICSGDD). The ICSGDD is proposed to meet annually as a forum to synergize multidisciplinary spine deformity research.
© 2017 Wiley Periodicals, Inc.

Entities:  

Keywords:  GWAS; congenital scoliosis; idiopathic scoliosis; natural history; phenotypic classification; spine deformity

Mesh:

Year:  2017        PMID: 29159998      PMCID: PMC6525596          DOI: 10.1002/ajmg.a.38550

Source DB:  PubMed          Journal:  Am J Med Genet A        ISSN: 1552-4825            Impact factor:   2.802


  4 in total

Review 1.  Congenital scoliosis: a narrative review and proposal of a treatment algorithm.

Authors:  Amer Sebaaly; Mohammad Daher; Bendy Salameh; Ali Ghoul; Samuel George; Sami Roukoz
Journal:  EFORT Open Rev       Date:  2022-05-05

Review 2.  MinION rapid sequencing: Review of potential applications in neurosurgery.

Authors:  Arpan Patel; Evgenii Belykh; Eric J Miller; Laeth L George; Nikolay L Martirosyan; Vadim A Byvaltsev; Mark C Preul
Journal:  Surg Neurol Int       Date:  2018-08-10

3.  Epigenetics for curve progression of adolescent idiopathic scoliosis.

Authors:  Yoji Ogura; Morio Matsumoto; Shiro Ikegawa; Kota Watanabe
Journal:  EBioMedicine       Date:  2018-10-10       Impact factor: 8.143

4.  Coding Variants Coupled With Rapid Modeling in Zebrafish Implicate Dynein Genes, dnaaf1 and zmynd10, as Adolescent Idiopathic Scoliosis Candidate Genes.

Authors:  Yunjia Wang; Zhenhao Liu; Guanteng Yang; Qile Gao; Lige Xiao; Jiong Li; Chaofeng Guo; Benjamin R Troutwine; Ryan S Gray; Lu Xie; Hongqi Zhang
Journal:  Front Cell Dev Biol       Date:  2020-11-04
  4 in total

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