Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Advanced Strategies for Eliminating the cccDNA of HBV.

Literature DB >> 29159681

Advanced Strategies for Eliminating the cccDNA of HBV.

Jingwu Dong¹, Jie Ying², Xiaoyan Qiu², Yu Lu², Miaomiao Zhang³.

Abstract

Persistent hepatitis B virus (HBV) infection of hepatocytes is associated with a covalently closed circular DNA (cccDNA) episome. Although serologic hepatitis B surface antigen tests are negative, the presence of cccDNA is obviously increased in HBeAg-positive patients compared with that in HBeAg-negative patients, inactive carriers and patients. Moreover, trace cccDNA levels can also be found in the liver cells of patients with resolved hepatitis B infections. Therefore, clearance of cccDNA in hepatocytes could be an effective cure for HBV. In this review, we summarize the strategies that have been employed to eliminate cccDNA in recent years and discuss the future development of treatments for chronic hepatitis B.

Entities: Chemical Disease Species

Keywords: Chronic hepatitis B therapy; HBV infection; Strategy; cccDNA

Mesh：

Substances：
DNA, Circular
DNA, Viral

Year: 2017 PMID： 29159681 DOI： 10.1007/s10620-017-4842-1

Source DB: PubMed Journal: Dig Dis Sci ISSN： 0163-2116 Impact factor: 3.199

71 in total

1. TGF-β triggers HBV cccDNA degradation through AID-dependent deamination.

Authors: Ying Qiao; Xiaoxu Han; Gefei Guan; Na Wu; Jianbo Sun; Vladimir Pak; Guoxin Liang
Journal: FEBS Lett Date: 2016-02-02 Impact factor: 4.124

Review 2. Attacking hepatitis B virus cccDNA--The holy grail to hepatitis B cure.

Authors: Julie Lucifora; Ulrike Protzer
Journal: J Hepatol Date: 2016-04 Impact factor: 25.083

3. Improved antiviral efficacy using TALEN-mediated homology directed recombination to introduce artificial primary miRNAs into DNA of hepatitis B virus.

Authors: Timothy Dreyer; Samantha Nicholson; Abdullah Ely; Patrick Arbuthnot; Kristie Bloom
Journal: Biochem Biophys Res Commun Date: 2016-08-30 Impact factor: 3.575

4. Stable inhibition of hepatitis B virus proteins by small interfering RNA expressed from viral vectors.

Authors: Michael D Moore; Michael J McGarvey; Rebecca A Russell; Bryan R Cullen; Myra O McClure
Journal: J Gene Med Date: 2005-07 Impact factor: 4.565

5. Generation of covalently closed circular DNA of hepatitis B viruses via intracellular recycling is regulated in a virus specific manner.

Authors: Josef Köck; Christine Rösler; Jing-Jing Zhang; Hubert E Blum; Michael Nassal; Christian Thoma
Journal: PLoS Pathog Date: 2010-09-02 Impact factor: 6.823

6. The CRISPR/Cas9 System Facilitates Clearance of the Intrahepatic HBV Templates In Vivo.

Authors: Su-Ru Lin; Hung-Chih Yang; Yi-Ting Kuo; Chun-Jen Liu; Ta-Yu Yang; Ku-Chun Sung; You-Yu Lin; Hurng-Yi Wang; Chih-Chiang Wang; Yueh-Chi Shen; Fang-Yi Wu; Jia-Horng Kao; Ding-Shinn Chen; Pei-Jer Chen
Journal: Mol Ther Nucleic Acids Date: 2014-08-19 Impact factor: 10.183

7. DNA Polymerase κ Is a Key Cellular Factor for the Formation of Covalently Closed Circular DNA of Hepatitis B Virus.

Authors: Yonghe Qi; Zhenchao Gao; Guangwei Xu; Bo Peng; Chenxuan Liu; Huan Yan; Qiyan Yao; Guoliang Sun; Yang Liu; Dingbin Tang; Zilin Song; Wenhui He; Yinyan Sun; Ju-Tao Guo; Wenhui Li
Journal: PLoS Pathog Date: 2016-10-26 Impact factor: 6.823

Review 8. Medical virology of hepatitis B: how it began and where we are now.

Authors: Wolfram H Gerlich
Journal: Virol J Date: 2013-07-20 Impact factor: 4.099

9. Alpha-interferon suppresses hepadnavirus transcription by altering epigenetic modification of cccDNA minichromosomes.

Authors: Fei Liu; Matthew Campagna; Yonghe Qi; Xuesen Zhao; Fang Guo; Chunxiao Xu; Sichen Li; Wenhui Li; Timothy M Block; Jinhong Chang; Ju-Tao Guo
Journal: PLoS Pathog Date: 2013-09-12 Impact factor: 6.823

10. IL6 Inhibits HBV Transcription by Targeting the Epigenetic Control of the Nuclear cccDNA Minichromosome.

Authors: Gianna Aurora Palumbo; Cecilia Scisciani; Natalia Pediconi; Leonardo Lupacchini; Dulce Alfalate; Francesca Guerrieri; Ludovica Calvo; Debora Salerno; Silvia Di Cocco; Massimo Levrero; Laura Belloni
Journal: PLoS One Date: 2015-11-18 Impact factor: 3.240

8 in total

Review 1. Host-Directed Antiviral Therapy.

Authors: Naveen Kumar; Shalini Sharma; Ram Kumar; Bhupendra N Tripathi; Sanjay Barua; Hinh Ly; Barry T Rouse
Journal: Clin Microbiol Rev Date: 2020-05-13 Impact factor: 26.132

2. Diagnostic Value of Detection of Pregenomic RNA in Sera of Hepatitis B Virus-Infected Patients with Different Clinical Outcomes.

Authors: Ni Lin; Aizhu Ye; Jinpiao Lin; Can Liu; Jinlan Huang; Ya Fu; Songhang Wu; Siyi Xu; Long Wang; Qishui Ou
Journal: J Clin Microbiol Date: 2020-01-28 Impact factor: 5.948

Advanced Strategies for Eliminating the cccDNA of HBV.

1. TGF-β triggers HBV cccDNA degradation through AID-dependent deamination.

Review 2. Attacking hepatitis B virus cccDNA--The holy grail to hepatitis B cure.

3. Improved antiviral efficacy using TALEN-mediated homology directed recombination to introduce artificial primary miRNAs into DNA of hepatitis B virus.

4. Stable inhibition of hepatitis B virus proteins by small interfering RNA expressed from viral vectors.

5. Generation of covalently closed circular DNA of hepatitis B viruses via intracellular recycling is regulated in a virus specific manner.

6. The CRISPR/Cas9 System Facilitates Clearance of the Intrahepatic HBV Templates In Vivo.

7. DNA Polymerase κ Is a Key Cellular Factor for the Formation of Covalently Closed Circular DNA of Hepatitis B Virus.

Review 8. Medical virology of hepatitis B: how it began and where we are now.

9. Alpha-interferon suppresses hepadnavirus transcription by altering epigenetic modification of cccDNA minichromosomes.

10. IL6 Inhibits HBV Transcription by Targeting the Epigenetic Control of the Nuclear cccDNA Minichromosome.

Review 1. Host-Directed Antiviral Therapy.

2. Diagnostic Value of Detection of Pregenomic RNA in Sera of Hepatitis B Virus-Infected Patients with Different Clinical Outcomes.

3. A Study on Pregenomic RNA and Factors Related to Hepatitis B Virus Infection Based on Real World.

Review 4. Mapping the Interactions of HBV cccDNA with Host Factors.

Review 5. Hepatitis B virus-host interactions and novel targets for viral cure.

Review 6. Recent Advances in Understanding, Diagnosing, and Treating Hepatitis B Virus Infection.

Review 7. Inhaled siRNA Formulations for Respiratory Diseases: From Basic Research to Clinical Application.

Review 8. Drug Discovery Study Aimed at a Functional Cure for HBV.