Meigs syndrome and elevated CA 125.

A patient presented with a pelvic mass, ascites, and pleural effusion. The serum CA 125 level was noted to be 226 U/mL (normal 5-35 U/mL). On surgical exploration, she had a benign fibroma-thecoma without malignant cytology in the ascitic fluid. Postoperatively, the pleural effusion resolved and the CA 125 decreased to 32 U/mL. This is the first reported case of Meigs syndrome and an elevated CA 125 level. As previously documented, elevated serum CA 125 does not always indicate malignancy.