Arnaud Plante1, Eric Baudin2, Christine Do Cao3, Olivia Hentic4, Olivier Dubreuil5, Eric Terrebonne6, Victoire Granger7, Denis Smith6, Catherine Lombard-Bohas1, Thomas Walter8. 1. Service d'hépatogastroentérologie et d'oncologie, hospices civils de Lyon, hôpital Edouard-Herriot, 5, place d'Arsonval, 69437 Lyon, France. 2. Service d'endocrino-oncologie, Gustave-Roussy, 94805 Villejuif, France. 3. Service d'endocrinologie, CHU de Lille, 59037 Lille, France. 4. Service de gastroentérologie, hôpital Beaujon, AP-HP, 92110 Bobigny, France. 5. Service de gastroentérologie, Pitiés-salpêtrière, AP-HP, 75651 Paris, France. 6. Service d'hépatogastroentérologie et d'oncologie digestive, hôpital de Haut-Lévêque, CHU de Bordeaux, 33600 Pessac, France. 7. Service de d'hépatogastroentérologie, CHU de Grenoble, 38700 Grenoble, France. 8. Service d'hépatogastroentérologie et d'oncologie, hospices civils de Lyon, hôpital Edouard-Herriot, 5, place d'Arsonval, 69437 Lyon, France. Electronic address: thomas.walter@chu-lyon.fr.
Abstract
BACKGROUND: Patients with advanced neuroendocrine tumors (NETs) benefit from an increasing number of treatments. The patient's preference could help physicians to choose among these options. Our patient-reported survey aims to compare the perceived tolerance of NETs treatments. METHODS: Patients treated by at least three different therapeutic options have evaluated their perceived tolerance from one (very good) to five (very poor) for each single treatment. Referent physician confirmed the type and ranking over time of each treatment. RESULTS: Two hundred and fourty two treatments have been evaluated by 54 patients. Among patients and NETs characteristics, only a female gender was associated with poor perceived tolerance. Median perceived tolerance increased from 1 (somatostatin analogs, peptide receptor radionuclide therapy (PRRT)), 2 (surgery, radiofrequency ablation and oral chemotherapy), 3 (interferon and everolimus), to 4 (liver embolization, sunitinib and intravenous chemotherapy). In taking somatostatin analogs as reference, the odd ratios for poor perceived tolerance were 1.7 [0.6-5.1] for oral chemotherapy, 2.2 [0.9-5.3] for surgery of the primary tumor, 2.4 [0.6-9.5] for radiofrequency ablation, 2.8 [1.1-7.3] for surgery of metastasis, 3.4 [1.4-7.9] for everolimus, 3.7 [1.6-8.5] for liver embolization, 4.9 [2.2-10.7] for intravenous chemotherapy and 5.9 [2.6-13.1] for sunitinib. Only PRRT had negative odd ratio. CONCLUSION: Our retrospective analysis suggests that perceived tolerance differ in between therapeutic options and may help physicians to sequence the therapeutic strategy.
BACKGROUND:Patients with advanced neuroendocrine tumors (NETs) benefit from an increasing number of treatments. The patient's preference could help physicians to choose among these options. Our patient-reported survey aims to compare the perceived tolerance of NETs treatments. METHODS:Patients treated by at least three different therapeutic options have evaluated their perceived tolerance from one (very good) to five (very poor) for each single treatment. Referent physician confirmed the type and ranking over time of each treatment. RESULTS: Two hundred and fourty two treatments have been evaluated by 54 patients. Among patients and NETs characteristics, only a female gender was associated with poor perceived tolerance. Median perceived tolerance increased from 1 (somatostatin analogs, peptide receptor radionuclide therapy (PRRT)), 2 (surgery, radiofrequency ablation and oral chemotherapy), 3 (interferon and everolimus), to 4 (liver embolization, sunitinib and intravenous chemotherapy). In taking somatostatin analogs as reference, the odd ratios for poor perceived tolerance were 1.7 [0.6-5.1] for oral chemotherapy, 2.2 [0.9-5.3] for surgery of the primary tumor, 2.4 [0.6-9.5] for radiofrequency ablation, 2.8 [1.1-7.3] for surgery of metastasis, 3.4 [1.4-7.9] for everolimus, 3.7 [1.6-8.5] for liver embolization, 4.9 [2.2-10.7] for intravenous chemotherapy and 5.9 [2.6-13.1] for sunitinib. Only PRRT had negative odd ratio. CONCLUSION: Our retrospective analysis suggests that perceived tolerance differ in between therapeutic options and may help physicians to sequence the therapeutic strategy.
Authors: Deborah Theiler; Marco Cattaneo; Lawrence O Dierickx; Peter Igaz; Simona Grozinsky-Glasberg; Claire Bournaud; Thomas O'Dorisio; M Sue O'Dorisio; Damian Wild; Emanuel Christ; Guillaume P Nicolas Journal: Cancers (Basel) Date: 2021-12-15 Impact factor: 6.639