| Literature DB >> 29157966 |
Benno H Ter Kuile1, Marloes Hoeksema2.
Abstract
Two recent studies show that incomplete repair of DNA damage due to oxidized nucleotides is crucial for reactive oxygen species (ROS)-related antimicrobial lethality. Using widely different experimental approaches they both reach the same conclusions on the role of downstream ROS production in cell killing upon exposure to bactericidal antimicrobials.Entities:
Keywords: DNA mismatch repair; MalE-LacZ hybrid protein; bactericidal antibiotics; reactive oxygen species; trimethoprim
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Year: 2017 PMID： 29157966 DOI： 10.1016/j.tim.2017.11.006
Source DB: PubMed Journal: Trends Microbiol ISSN： 0966-842X Impact factor: 17.079