Literature DB >> 29157931

Alternatives to hysterectomy: The burden of fibroids and the quality of life.

Chelsea Fortin1, Rebecca Flyckt1, Tommaso Falcone2.   

Abstract

Uterine fibroids are the most common benign tumor in reproductive-aged women. While the majority of women are asymptomatic, those with symptoms may suffer from abnormal uterine bleeding, infertility, pelvic pain or pressure, and urinary dysfunction. Fibroids represent a significant healthcare burden for women and society as a whole. Women with fibroids have compromised overall quality of life and impairment in many specific domains including work productivity, sexuality, self-image, relationships, and social emotional and physical well-being. Many women are reluctant to ask for help and delay seeking treatment. To date, myomectomy remains the gold standard for treating fibroid-related symptoms in reproductive-aged women. However, many less invasive uterine preserving approaches have been developed. Quality of life is improved in many women following treatment for fibroids. This article aims to provide an overview of the substantial impact of fibroids on health-related quality of life.
Copyright © 2017. Published by Elsevier Ltd.

Entities:  

Keywords:  Fibroids; Health-related quality of life; Leiomyomas; Myomas; Quality of life

Mesh:

Year:  2017        PMID: 29157931     DOI: 10.1016/j.bpobgyn.2017.10.001

Source DB:  PubMed          Journal:  Best Pract Res Clin Obstet Gynaecol        ISSN: 1521-6934            Impact factor:   5.237


  9 in total

1.  Increased Expression of Fibroblast Activation Protein is Associated with Autophagy Dysregulation and Oxidative Stress in Obese Women with Uterine Fibroids.

Authors:  Nashwa Maghraby; Amira M El Noweihi; Nagla T El-Melegy; Nashwa A M Mostafa; Ahmed M Abbas; Heba E M El-Deek; Eman Radwan
Journal:  Reprod Sci       Date:  2021-11-29       Impact factor: 3.060

2.  The Selective Progesterone Receptor Modulator Ulipristal Acetate Inhibits the Activity of the Glucocorticoid Receptor.

Authors:  Benjamin Small; Charles E F Millard; Edwina P Kisanga; Andreanna Burman; Anika Anam; Clare Flannery; Ayman Al-Hendy; Shannon Whirledge
Journal:  J Clin Endocrinol Metab       Date:  2020-03-01       Impact factor: 5.958

3.  Mediator Kinase Disruption in MED12-Mutant Uterine Fibroids From Hispanic Women of South Texas.

Authors:  Min Ju Park; Hailian Shen; Nam Hee Kim; Fangjian Gao; Courtney Failor; Jennifer F Knudtson; Jessica McLaughlin; Sunil K Halder; Tuomas A Heikkinen; Pia Vahteristo; Ayman Al-Hendy; Robert S Schenken; Thomas G Boyer
Journal:  J Clin Endocrinol Metab       Date:  2018-11-01       Impact factor: 5.958

Review 4.  Wnt/β-catenin signaling pathway in uterine leiomyoma: role in tumor biology and targeting opportunities.

Authors:  Malak El Sabeh; Subbroto Kumar Saha; Sadia Afrin; Md Soriful Islam; Mostafa A Borahay
Journal:  Mol Cell Biochem       Date:  2021-05-17       Impact factor: 3.842

5.  Burden of Uterine Fibroids: An African Perspective, A Call for Action and Opportunity for Intervention.

Authors:  P Igboeli; W Walker; A McHugh; A Sultan; A Al-Hendy
Journal:  Curr Opin Gynecol Obstet       Date:  2019-08-11

6.  Proposed Key Characteristics of Female Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Data in Hazard Assessment.

Authors:  Ulrike Luderer; Brenda Eskenazi; Russ Hauser; Kenneth S Korach; Cliona M McHale; Francisco Moran; Linda Rieswijk; Gina Solomon; Osamu Udagawa; Luoping Zhang; Marya Zlatnik; Lauren Zeise; Martyn T Smith
Journal:  Environ Health Perspect       Date:  2019-07-19       Impact factor: 9.031

Review 7.  What We Know about the Long-Term Risks of Hysterectomy for Benign Indication-A Systematic Review.

Authors:  Obianuju Sandra Madueke-Laveaux; Amro Elsharoud; Ayman Al-Hendy
Journal:  J Clin Med       Date:  2021-11-16       Impact factor: 4.241

8.  The Burden of Uterine Fibroids from the Perspective of US Women Participating in Open-Ended Interviews.

Authors:  Elke Hunsche; Viatcheslav Rakov; Kayla Scippa; Brooke Witherspoon; Laura McKain
Journal:  Womens Health Rep (New Rochelle)       Date:  2022-03-04

9.  Comparison of (Cost-)Effectiveness of Magnetic Resonance Image-Guided High-Intensity-Focused Ultrasound With Standard (Minimally) Invasive Fibroid Treatments: Protocol for a Multicenter Randomized Controlled Trial (MYCHOICE).

Authors:  Kimberley J Anneveldt; Ingrid M Nijholt; Joke M Schutte; Jeroen R Dijkstra; Geert W J Frederix; Erwin Ista; Inez M Verpalen; Sebastiaan Veersema; Judith A F Huirne; Wouter J K Hehenkamp; Martijn F Boomsma
Journal:  JMIR Res Protoc       Date:  2021-11-24
  9 in total

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