Literature DB >> 29157722

Ca2+ leak-What is it? Why should we care? Can it be managed?

Penelope A Boyden1, Godfrey L Smith2.   

Abstract

For arrhythmia triggers that are secondary to dysfunctional intracellular Ca2+ cycling, there are few, if any, agents that specifically target the Ca2+ handling machinery. However, several candidates have been proposed in the literature. Here we review the idea that these agents or their derivatives will prove invaluable in clinical applications in the future.
Copyright © 2017 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Arrhythmia; Calcium; Delayed afterdepolarization; Pharmacology; Trigger

Mesh：

Substances：

Year:  2017        PMID： 29157722      PMCID： PMC5878990          DOI： 10.1016/j.hrthm.2017.11.018

Source DB:  PubMed          Journal:  Heart Rhythm        ISSN： 1547-5271            Impact factor:   6.343


  76 in total

1.  PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.

Authors:  S O Marx; S Reiken; Y Hisamatsu; T Jayaraman; D Burkhoff; N Rosemblit; A R Marks
Journal:  Cell       Date:  2000-05-12       Impact factor: 41.582

2.  Sarcoplasmic reticulum Ca2+ and heart failure: roles of diastolic leak and Ca2+ transport.

Authors:  Donald M Bers; David A Eisner; Hector H Valdivia
Journal:  Circ Res       Date:  2003-09-19       Impact factor: 17.367

3.  KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart.

Authors:  M E Anderson; A P Braun; Y Wu; T Lu; Y Wu; H Schulman; R J Sung
Journal:  J Pharmacol Exp Ther       Date:  1998-12       Impact factor: 4.030

Review 4.  Role of ranolazine in the prevention and treatment of atrial fibrillation: A meta-analysis of randomized clinical trials.

Authors:  Mengqi Gong; Zhiwei Zhang; Nikolaos Fragakis; Panagiotis Korantzopoulos; Konstantinos P Letsas; Guangping Li; Gan-Xin Yan; Tong Liu
Journal:  Heart Rhythm       Date:  2016-10-13       Impact factor: 6.343

5.  Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knockout mice.

Authors:  Na Li; Tiannan Wang; Wei Wang; Michael J Cutler; Qiongling Wang; Niels Voigt; David S Rosenbaum; Dobromir Dobrev; Xander H T Wehrens
Journal:  Circ Res       Date:  2011-12-08       Impact factor: 17.367

6.  Protective effect of JTV519, a new 1,4-benzothiazepine derivative, on prolonged myocardial preservation.

Authors:  M Hachida; S Kihara; M Nonoyama; H Koyanagi
Journal:  J Card Surg       Date:  1999 May-Jun       Impact factor: 1.620

7.  Shortened Ca2+ signaling refractoriness underlies cellular arrhythmogenesis in a postinfarction model of sudden cardiac death.

Authors:  Andriy E Belevych; Dmitry Terentyev; Radmila Terentyeva; Hsiang-Ting Ho; Inna Gyorke; Ingrid M Bonilla; Cynthia A Carnes; George E Billman; Sandor Györke
Journal:  Circ Res       Date:  2012-01-05       Impact factor: 17.367

8.  Effects of temperature on cycle length dependent changes and restitution of action potential duration in guinea pig ventricular muscle.

Authors:  H Bjørnstad; P M Tande; D A Lathrop; H Refsum
Journal:  Cardiovasc Res       Date:  1993-06       Impact factor: 10.787

9.  Dual mechanism of a natural CaMKII inhibitor.

Authors:  Rebekah S Vest; Kurtis D Davies; Heather O'Leary; J David Port; K Ulrich Bayer
Journal:  Mol Biol Cell       Date:  2007-10-17       Impact factor: 4.138

10.  The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments.

Authors:  Zsófia Kohajda; Nikolett Farkas-Morvay; Norbert Jost; Norbert Nagy; Amir Geramipour; András Horváth; Richárd S Varga; Tibor Hornyik; Claudia Corici; Károly Acsai; Balázs Horváth; János Prorok; Balázs Ördög; Szilvia Déri; Dániel Tóth; Jouko Levijoki; Piero Pollesello; Tuula Koskelainen; Leena Otsomaa; András Tóth; István Baczkó; István Leprán; Péter P Nánási; Julius Gy Papp; András Varró; László Virág
Journal:  PLoS One       Date:  2016-11-10       Impact factor: 3.240
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  3 in total

1.  Mechanisms of Calcium Leak from Cardiac Sarcoplasmic Reticulum Revealed by Statistical Mechanics.

Authors:  Anna V Maltsev; Michael D Stern; Victor A Maltsev
Journal:  Biophys J       Date:  2019-05-03       Impact factor: 4.033

2.  Nitro-fatty acids suppress ischemic ventricular arrhythmias by preserving calcium homeostasis.

Authors:  Martin Mollenhauer; Dennis Mehrkens; Anna Klinke; Max Lange; Lisa Remane; Kai Friedrichs; Simon Braumann; Simon Geißen; Sakine Simsekyilmaz; Felix S Nettersheim; Samuel Lee; Gabriel Peinkofer; Anne C Geisler; Bianca Geis; Alexander P Schwoerer; Lucie Carrier; Bruce A Freeman; Matthias Dewenter; Xiaojing Luo; Ali El-Armouche; Michael Wagner; Matti Adam; Stephan Baldus; Volker Rudolph
Journal:  Sci Rep       Date:  2020-09-18       Impact factor: 4.379

Review 3.  Role of PKD2 in the endoplasmic reticulum calcium homeostasis.

Authors:  Xiong Liu; Jingfeng Tang; Xing-Zhen Chen
Journal:  Front Physiol       Date:  2022-08-10       Impact factor: 4.755
  3 in total

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