Laura Mählmann1, Markus Gerber2, Raoul I Furlano3, Corinne Legeret3, Nadeem Kalak4, Edith Holsboer-Trachsler4, Serge Brand5. 1. University of Basel, Psychiatric Clinics (UPK), Centre for Affective, Stress and Sleep Disorders (ZASS), Basel, Switzerland; Maastricht Economic and Social Research Institute on Innovation and Technology (MERIT), Maastricht University, Maastricht, The Netherlands. 2. University of Basel, Department of Sport, Exercise and Health, Division of Sport and Psychosocial Health, Basel, Switzerland. 3. University Children's Hospital Basel, Paediatric Gastroenterology & Nutrition, Basel, Switzerland. 4. University of Basel, Psychiatric Clinics (UPK), Centre for Affective, Stress and Sleep Disorders (ZASS), Basel, Switzerland. 5. University of Basel, Psychiatric Clinics (UPK), Centre for Affective, Stress and Sleep Disorders (ZASS), Basel, Switzerland; University of Basel, Department of Sport, Exercise and Health, Division of Sport and Psychosocial Health, Basel, Switzerland; Kermanshah University of Medical Sciences (KUMS), Substance Abuse Prevention Research Center and Sleep Disorders Prevention Center, Kermanshah, Iran. Electronic address: serge.brand@upkbs.ch.
Abstract
OBJECTIVE: Poor sleep and higher inflammation markers are associated, and impaired sleep quality is common among patients with inflammatory bowel disease (IBD). However, information on sleep among children and adolescents with IBD is currently lacking. The aims of the present study were to compare subjective and objective sleep of children and adolescents with IBD with healthy controls and to shed more light on the relationship between sleep and inflammation. We expected that poor sleep, as assessed via sleep electroencephalography recordings, would be observed among participants with IBD, but particularly among participants in an active state of disease. Furthermore, we expected that poor sleep and higher inflammatory markers would be associated. METHODS: A total of 47 children and adolescents participated in the study; 23 were diagnosed with IBD (mean age: 13.88 years, 44% female). The IBD group was divided into a medically well adjusted "remission-group" (IBD-RE; n = 14) and a group with an "active state of disease" (IBD-AD; n = 8). Healthy controls (HC; n = 24) were age and gender matched. Participants completed self-rating questionnaires for subjective sleep disturbances. Anthropometric data, acute and chronic inflammatory markers (C-reactive protein [CRP] and erythrocyte sedimentation rate [ESR]) and objective sleep were considered. RESULTS: Compared to HC and IBD-RE, IBD-AD patients showed impaired objective sleep patterns (eg, more awakenings, longer sleep latency, and reduced stage 3 sleep). Linear relationships described the correlation between higher ESR and more stage 4 (minutes, percentage) sleep. Nonlinear relationships described the relation between ESR and subjective sleep quality (inverse U-shaped) and between CRP and sleep latency (U-shaped). CONCLUSION: In children and adolescents with an active IBD, objective sleep was impaired and overall sleep quality and inflammation indices were associated in a complex manner. It seems advisable to include assessment of subjective sleep quality in the care of pediatric IBD patients as an additional indicator for objective sleep disturbances and inflammation. TRIAL REGISTRATION NUMBER: NCT02264275.
OBJECTIVE: Poor sleep and higher inflammation markers are associated, and impaired sleep quality is common among patients with inflammatory bowel disease (IBD). However, information on sleep among children and adolescents with IBD is currently lacking. The aims of the present study were to compare subjective and objective sleep of children and adolescents with IBD with healthy controls and to shed more light on the relationship between sleep and inflammation. We expected that poor sleep, as assessed via sleep electroencephalography recordings, would be observed among participants with IBD, but particularly among participants in an active state of disease. Furthermore, we expected that poor sleep and higher inflammatory markers would be associated. METHODS: A total of 47 children and adolescents participated in the study; 23 were diagnosed with IBD (mean age: 13.88 years, 44% female). The IBD group was divided into a medically well adjusted "remission-group" (IBD-RE; n = 14) and a group with an "active state of disease" (IBD-AD; n = 8). Healthy controls (HC; n = 24) were age and gender matched. Participants completed self-rating questionnaires for subjective sleep disturbances. Anthropometric data, acute and chronic inflammatory markers (C-reactive protein [CRP] and erythrocyte sedimentation rate [ESR]) and objective sleep were considered. RESULTS: Compared to HC and IBD-RE, IBD-ADpatients showed impaired objective sleep patterns (eg, more awakenings, longer sleep latency, and reduced stage 3 sleep). Linear relationships described the correlation between higher ESR and more stage 4 (minutes, percentage) sleep. Nonlinear relationships described the relation between ESR and subjective sleep quality (inverse U-shaped) and between CRP and sleep latency (U-shaped). CONCLUSION: In children and adolescents with an active IBD, objective sleep was impaired and overall sleep quality and inflammation indices were associated in a complex manner. It seems advisable to include assessment of subjective sleep quality in the care of pediatric IBD patients as an additional indicator for objective sleep disturbances and inflammation. TRIAL REGISTRATION NUMBER: NCT02264275.
Authors: Heba N Iskandar; Emily E Linan; Ami Patel; Renee Moore; Yi Lasanajak; C Prakash Gyawali; Gregory S Sayuk; Matthew A Ciorba Journal: Sci Rep Date: 2020-02-06 Impact factor: 4.379
Authors: Azita Chehri; Serge Brand; Nastaran Goldaste; Sodabeh Eskandari; Annette Brühl; Dena Sadeghi Bahmani; Habibolah Khazaie Journal: Int J Environ Res Public Health Date: 2020-09-28 Impact factor: 3.390