Literature DB >> 29157485

A Ferriere1, V Kerlan2, A Tabarin3.   

Abstract

The 2017 Endocrine Society annual meeting included several communications and debates on the conservative adrenal surgery in bilateral hereditary pheochromocytomas (BHP), bilateral adrenal macronodular hyperplasia (BAMH) and primary hyperaldosteronism (PHA). The general principle is to preserve a part of the adrenal cortex to prevent the occurrence of a definitive adrenal insufficiency. In BHP, cortical sparing surgery allows more than 50% of patients to maintain normal corticotropic function at 10 years with a low recurrence rate (~ 10%). Since the adrenal medulla cannot be removed entirely, recurrence seems inevitable and long-term follow-up is essential. Individual risk of malignancy must be taken into account. In BAMH responsible for Cushing syndrome, unilateral adrenalectomy induces a normalization of urinary free cortisol in 92 to 100% of cases and even corticotropic insufficiency in 40 to 100% of cases. This is most often transient. Late recurrences of Cushing's syndrome may occur in 13 to 60% of cases. Prolonged patient monitoring is therefore essential. In PAH with lateralized aldosterone production, minimally invasive partial adrenal surgery, which consists of removing only the adrenal adenoma visualized at TDM, allows an improvement blood pressure in about 94% of patients. However, failure or recurrence may occur. Its place therefore remains marginal in the treatment of the lateralized PAHs.
© 2017 Elsevier Masson SAS. Tous droits réservés.

Entities:  

Keywords:  Bilateral macronodular adrenal hyperplasia; Bilateral pheochromocytoma; Chirurgie d’épargne surrénalienne; Conn adenoma; Cortical sparing surgery; Hyperaldostéronisme primaire latéralisé; Hyperplasie macronodulaire bilatérale des surrénales; Phéochromocytomes bilatéraux

Mesh:

Year:  2017        PMID: 29157485     DOI: 10.1016/S0003-4266(17)30921-6

Source DB:  PubMed          Journal:  Ann Endocrinol (Paris)        ISSN: 0003-4266            Impact factor:   2.478


  2 in total

1.  Case Report: Pheochromocytoma and Synchronous Neuroblastoma in a Family With Hereditary Pheochromocytoma Associated With a MAX Deleterious Variant.

Authors:  Diana Borges Duarte; Lia Ferreira; Ana P Santos; Cláudia Costa; Jorge Lima; Catarina Santos; Mariana Afonso; Manuel R Teixeira; Rui Carvalho; Maria Helena Cardoso
Journal:  Front Endocrinol (Lausanne)       Date:  2021-03-17       Impact factor: 5.555

Review 2.  Minimally Invasive Partial vs. Total Adrenalectomy for the Treatment of Unilateral Primary Aldosteronism: A Systematic Review and Meta-Analysis.

Authors:  Rocco Simone Flammia; Umberto Anceschi; Antonio Tufano; Eugenio Bologna; Flavia Proietti; Alfredo Maria Bove; Leonardo Misuraca; Riccardo Mastroianni; Giuseppe Tirone; Alessandro Carrara; Lorenzo Luciani; Tommaso Cai; Costantino Leonardo; Giuseppe Simone
Journal:  J Clin Med       Date:  2022-02-25       Impact factor: 4.241

  2 in total

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