Yusuf Ahmed1, Marko Popovic1, Bo Angela Wan1, Michael Lam1, Henry Lam1, Vithusha Ganesh1, Milica Milakovic1, Carlo DeAngelis2, Leila Malek1, Edward Chow3. 1. Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Science Centre, University of Toronto, Toronto, Ontario, Canada. 2. Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Science Centre, University of Toronto, Toronto, Ontario, Canada; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada. 3. Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Science Centre, University of Toronto, Toronto, Ontario, Canada. Edward.chow@sunnybrook.ca.
Abstract
BACKGROUND: Pain is reported in approximately 50-70% of cancer patients. Studies on gender differences in perceived pain generally report lower pain thresholds and increased pain prevalence in women, which may be attributed to gender-specific behaviors, stereotypes, and unknown etiological factors. There are sparse and inconclusive results on gender differences in self-perceived pain in the cancer setting. The aim of this article was to examine the effect of gender on baseline perceived pain intensity in cancer patients through a meta-analysis. METHODS: A literature search was conducted using Ovid MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials [1947-2016] to identify observational studies and controlled trials that reported on gender-specific pain intensity in cancer patients. Using random-effects modeling, weighted mean differences and 95% confidence intervals (CI) were used to estimate the effect of gender on pain severity in cancer patients. A P value of less than 0.05 was considered statistically significant. RESULTS: Of the 1,911 search results reviewed, 13 studies were included. The weighted mean difference (95% CI) in pain intensity was as follows: -0.26 (95% CI: -0.57 to 0.04, P=0.09) for the 0-10 Numerical Rating Scale (NRS) group (n=3,752, 9 studies). When restricted to only patients with advanced cancer, the weighted mean difference was -0.08 (95% CI: -0.36 to 0.20, P=0.58) (n=2,762, 4 studies). The weighted mean difference in the Brief Pain Inventory scores between males and females was 0.03 (95% CI: -1.23 to 1.29, P=0.96) (n=521, 4 studies). CONCLUSIONS: Baseline perceived pain intensity in cancer patients did not significantly differ based on gender.
BACKGROUND:Pain is reported in approximately 50-70% of cancerpatients. Studies on gender differences in perceived pain generally report lower pain thresholds and increased pain prevalence in women, which may be attributed to gender-specific behaviors, stereotypes, and unknown etiological factors. There are sparse and inconclusive results on gender differences in self-perceived pain in the cancer setting. The aim of this article was to examine the effect of gender on baseline perceived pain intensity in cancerpatients through a meta-analysis. METHODS: A literature search was conducted using Ovid MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials [1947-2016] to identify observational studies and controlled trials that reported on gender-specific pain intensity in cancerpatients. Using random-effects modeling, weighted mean differences and 95% confidence intervals (CI) were used to estimate the effect of gender on pain severity in cancerpatients. A P value of less than 0.05 was considered statistically significant. RESULTS: Of the 1,911 search results reviewed, 13 studies were included. The weighted mean difference (95% CI) in pain intensity was as follows: -0.26 (95% CI: -0.57 to 0.04, P=0.09) for the 0-10 Numerical Rating Scale (NRS) group (n=3,752, 9 studies). When restricted to only patients with advanced cancer, the weighted mean difference was -0.08 (95% CI: -0.36 to 0.20, P=0.58) (n=2,762, 4 studies). The weighted mean difference in the Brief Pain Inventory scores between males and females was 0.03 (95% CI: -1.23 to 1.29, P=0.96) (n=521, 4 studies). CONCLUSIONS: Baseline perceived pain intensity in cancerpatients did not significantly differ based on gender.
Authors: Morten Thronæs; Trude Rakel Balstad; Cinzia Brunelli; Erik Torbjørn Løhre; Pål Klepstad; Ola Magne Vagnildhaug; Stein Kaasa; Anne Kari Knudsen; Tora Skeidsvoll Solheim Journal: Support Care Cancer Date: 2019-07-09 Impact factor: 3.603
Authors: Abdulaziz Alodhayani; Khalid M Almutairi; Jason M Vinluan; Norah Alsadhan; Turky H Almigbal; Wadi B Alonazi; Mohammed Ali Batais Journal: Front Psychol Date: 2021-08-26