Kobra Bahrampour Juybari1, Ghasem Ebrahimi2, Mohammad Amin Momeni Moghaddam2, Gholamreza Asadikaram3, Masoud Torkzadeh-Mahani4, Mahboobeh Akbari2, Solmaz Mirzamohammadi5, Atieh Karimi6, Mohammad Hadi Nematollahi7. 1. Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran. 2. Department of Biochemistry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran. 3. Department of Biochemistry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran; Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran. 4. Biotechnology Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran. 5. Department of Pharmacology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran. 6. Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran. Electronic address: atieh.karimy@gmail.com. 7. Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran. Electronic address: mh.nematollahi@yahoo.com.
Abstract
BACKGROUND: Environmental factors that are involved in the development of autoimmune diseases include bacteria, viruses, and xenobiotics such as chemicals, drugs, and metals. Regarding the metals, a number of studies have demonstrated that oxidative stress is one of the well-directed pathways of arsenic-induced tissue damages. This study was designed to explore the serum concentrations of arsenic and its correlation with markers associated with oxidative stress in relapsing-remitting MS (RRMS) patients. METHODS: This case-controlled study comprised 50 patients with RRMS and 50 healthy subjects. Serum arsenic levels, total antioxidant potential, malondialdehyde (MDA), and lactate levels were measured. RESULTS: The arsenic value, MDA, and lactate levels were elevated meaningfully while FRAP level significantly was decreased in RRMS patients with respect to healthy subjects (P <0.05). Furthermore, arsenic serum levels were positively correlated with serum concentrations of MDA and lactate. In contrast, serum levels were negatively correlated to FRAP values in RRMS patients. CONCLUSION: Taken together, the association between arsenic level and oxidative stress parameters supports the hypothesis that high serum arsenic levels may play a critical role in the pathogenesis of MS progression.
BACKGROUND: Environmental factors that are involved in the development of autoimmune diseases include bacteria, viruses, and xenobiotics such as chemicals, drugs, and metals. Regarding the metals, a number of studies have demonstrated that oxidative stress is one of the well-directed pathways of arsenic-induced tissue damages. This study was designed to explore the serum concentrations of arsenic and its correlation with markers associated with oxidative stress in relapsing-remitting MS (RRMS) patients. METHODS: This case-controlled study comprised 50 patients with RRMS and 50 healthy subjects. Serum arsenic levels, total antioxidant potential, malondialdehyde (MDA), and lactate levels were measured. RESULTS: The arsenic value, MDA, and lactate levels were elevated meaningfully while FRAP level significantly was decreased in RRMS patients with respect to healthy subjects (P <0.05). Furthermore, arsenic serum levels were positively correlated with serum concentrations of MDA and lactate. In contrast, serum levels were negatively correlated to FRAP values in RRMS patients. CONCLUSION: Taken together, the association between arsenic level and oxidative stress parameters supports the hypothesis that high serum arsenic levels may play a critical role in the pathogenesis of MS progression.
Authors: Alireza Bastin; Saba Fooladi; Amir Hossein Doustimotlagh; Sina Vakili; Amir Hashem Aminizadeh; Sanaz Faramarz; Hamidreza Shiri; Mohammad Hadi Nematollahi Journal: PLoS One Date: 2022-04-06 Impact factor: 3.240