Literature DB >> 29156129

Small Molecule Mitochondrial Uncouplers and Their Therapeutic Potential.

Elizabeth S Childress1, Stephanie J Alexopoulos2, Kyle L Hoehn2,3, Webster L Santos1.   

Abstract

Small molecule mitochondrial uncouplers transport protons from the mitochondrial inner membrane space into the mitochondrial matrix independent of ATP synthase, uncoupling nutrient metabolism from ATP generation. The therapeutic potential of mitochondrial uncouplers has been investigated for the treatment of metabolic diseases such as obesity and type 2 diabetes (T2D), ischemia-reperfusion injury, and neurodegenerative diseases. This communication will review the small molecule mitochondrial uncouplers reported to date and explore their potential as therapeutics.

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Year:  2017        PMID： 29156129     DOI： 10.1021/acs.jmedchem.7b01182

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  29 in total

Review 1.  Use the Protonmotive Force: Mitochondrial Uncoupling and Reactive Oxygen Species.

Authors:  Brandon J Berry; Adam J Trewin; Andrea M Amitrano; Minsoo Kim; Andrew P Wojtovich
Journal:  J Mol Biol       Date:  2018-04-04       Impact factor: 5.469

2.  [1,2,5]Oxadiazolo[3,4-b]pyrazine-5,6-diamine Derivatives as Mitochondrial Uncouplers for the Potential Treatment of Nonalcoholic Steatohepatitis.

Authors:  Elizabeth S Childress; Joseph M Salamoun; Stefan R Hargett; Stephanie J Alexopoulos; Sing-Young Chen; Divya P Shah; José Santiago-Rivera; Christopher J Garcia; Yumin Dai; Simon P Tucker; Kyle L Hoehn; Webster L Santos
Journal:  J Med Chem       Date:  2020-02-17       Impact factor: 7.446

3.  Cannabinol inhibits oxytosis/ferroptosis by directly targeting mitochondria independently of cannabinoid receptors.

Authors:  Zhibin Liang; David Soriano-Castell; Devin Kepchia; Brendan M Duggan; Antonio Currais; David Schubert; Pamela Maher
Journal:  Free Radic Biol Med       Date:  2022-01-06       Impact factor: 7.376

4.  Synthesis of a fluorinated pyronin that enables blue light to rapidly depolarize mitochondria.

Authors:  Zhe Gao; Krishna K Sharma; Angelo E Andres; Brandon Walls; Fadel Boumelhem; Zachary R Woydziak; Blake R Peterson
Journal:  RSC Med Chem       Date:  2022-03-07

5.  Mitochondrial uncouplers induce proton leak by activating AAC and UCP1.

Authors:  Ambre M Bertholet; Andrew M Natale; Paola Bisignano; Junji Suzuki; Andriy Fedorenko; James Hamilton; Tatiana Brustovetsky; Lawrence Kazak; Ryan Garrity; Edward T Chouchani; Nickolay Brustovetsky; Michael Grabe; Yuriy Kirichok
Journal:  Nature       Date:  2022-05-25       Impact factor: 69.504

Review 6.  Mitochondrial pathways in human health and aging.

Authors:  Rebecca Bornstein; Brenda Gonzalez; Simon C Johnson
Journal:  Mitochondrion       Date:  2020-07-30       Impact factor: 4.160

7.  Common gut microbial metabolites of dietary flavonoids exert potent protective activities in β-cells and skeletal muscle cells.

Authors:  Benjamin F Bitner; Jason D Ray; Kyle B Kener; Jacob A Herring; Josie A Tueller; Deborah K Johnson; Claudia M Tellez Freitas; Dane W Fausnacht; Mitchell E Allen; Alexander H Thomson; K Scott Weber; Ryan P McMillan; Matthew W Hulver; David A Brown; Jeffery S Tessem; Andrew P Neilson
Journal:  J Nutr Biochem       Date:  2018-09-15       Impact factor: 6.048

8.  Exploiting activity cliffs for building pharmacophore models and comparison with other pharmacophore generation methods: sphingosine kinase 1 as case study.

Authors:  Lubabah A Mousa; Ma'mon M Hatmal; Mutasem Taha
Journal:  J Comput Aided Mol Des       Date:  2022-01-21       Impact factor: 3.686

Review 9.  Mitochondria as a therapeutic target for common pathologies.

Authors:  Michael P Murphy; Richard C Hartley
Journal:  Nat Rev Drug Discov       Date:  2018-11-05       Impact factor: 84.694

Review 10.  Targeting Energy Expenditure-Drugs for Obesity Treatment.

Authors:  Carlos M Jimenez-Munoz; Marta López; Fernando Albericio; Kamil Makowski
Journal:  Pharmaceuticals (Basel)       Date:  2021-05-06
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