Background: In the United Kingdom, rising levels of disease due to Neisseria meningitidis serogroup W clonal complex (cc) sequence type (ST) 11 (MenW:cc11) strains led to introduction of meningococcal conjugate vaccine (MenACWY) for teenagers. We investigated the impact of immunization on carriage of meningococci targeted by the vaccine, using whole-genome sequencing of isolates recovered from a cohort of vaccinated university students. Methods: Strain designation data were extracted from whole-genome sequencing data. Genomes from carried and invasive MenW:cc11 strains were compared using a gene-by-gene approach. Serogrouping identified isolates expressing capsule antigens targeted by the vaccine. Results: Isolates with a W: P1.5,2: F1-1: ST-11 (cc11) designation and belonging to the emerging 2013-strain of the South American-United Kingdom MenW:cc11 sublineage were responsible for an increase in carried group W strains. A multifocal expansion was evident, with close transmission networks extending beyond individual dormitories. Carried group Y isolates were predominantly from cc23 but showed significant heterogeneity, and individual strain designations were only sporadically recovered. No shifts toward acapsulate phenotypes were detected in targeted meningococcal populations. Conclusions: In a setting with high levels of MenACWY use, expansion of capsule-expressing isolates from the 2013-strain of MenW:cc11 but not MenY:cc23 isolates is indicative of differential susceptibilities to vaccine-induced immunity.
Background: In the United Kingdom, rising levels of disease due to Neisseria meningitidis serogroup W clonal complex (cc) sequence type (ST) 11 (MenW:cc11) strains led to introduction of meningococcal conjugate vaccine (MenACWY) for teenagers. We investigated the impact of immunization on carriage of meningococci targeted by the vaccine, using whole-genome sequencing of isolates recovered from a cohort of vaccinated university students. Methods: Strain designation data were extracted from whole-genome sequencing data. Genomes from carried and invasive MenW:cc11 strains were compared using a gene-by-gene approach. Serogrouping identified isolates expressing capsule antigens targeted by the vaccine. Results: Isolates with a W: P1.5,2: F1-1: ST-11 (cc11) designation and belonging to the emerging 2013-strain of the South American-United Kingdom MenW:cc11 sublineage were responsible for an increase in carried group W strains. A multifocal expansion was evident, with close transmission networks extending beyond individual dormitories. Carried group Y isolates were predominantly from cc23 but showed significant heterogeneity, and individual strain designations were only sporadically recovered. No shifts toward acapsulate phenotypes were detected in targeted meningococcal populations. Conclusions: In a setting with high levels of MenACWY use, expansion of capsule-expressing isolates from the 2013-strain of MenW:cc11 but not MenY:cc23 isolates is indicative of differential susceptibilities to vaccine-induced immunity.
Authors: Martin V R Weber; Heike Claus; Martin C J Maiden; Matthias Frosch; Ulrich Vogel Journal: Int J Med Microbiol Date: 2006-07-28 Impact factor: 3.473
Authors: Paul A Kristiansen; Fabien Diomandé; Absatou Ky Ba; Idrissa Sanou; Abdoul-Salam Ouédraogo; Rasmata Ouédraogo; Lassana Sangaré; Denis Kandolo; Flavien Aké; Inger Marie Saga; Thomas A Clark; Lara Misegades; Stacey W Martin; Jennifer Dolan Thomas; Sylvestre R Tiendrebeogo; Musa Hassan-King; Mamoudou H Djingarey; Nancy E Messonnier; Marie-Pierre Préziosi; F Marc Laforce; Dominique A Caugant Journal: Clin Infect Dis Date: 2012-10-19 Impact factor: 9.079
Authors: Shamez N Ladhani; Kazim Beebeejaun; Jay Lucidarme; Helen Campbell; Steve Gray; Ed Kaczmarski; Mary E Ramsay; Ray Borrow Journal: Clin Infect Dis Date: 2014-11-10 Impact factor: 9.079
Authors: Hope H Biswas; George S Han; Kristen Wendorf; Kathleen Winter; Jennifer Zipprich; Tara Perti; Linda Martinez; Aileen Arellano; Jennifer L Kyle; Peng Zhang; Kathleen Harriman Journal: MMWR Morb Mortal Wkly Rep Date: 2016-05-27 Impact factor: 17.586
Authors: Jay Lucidarme; Kevin J Scott; Roisin Ure; Andrew Smith; Diane Lindsay; Bianca Stenmark; Susanne Jacobsson; Hans Fredlund; J Claire Cameron; Alison Smith-Palmer; Jim McMenamin; Steve J Gray; Helen Campbell; Shamez Ladhani; Jamie Findlow; Paula Mölling; Ray Borrow Journal: Euro Surveill Date: 2016-11-10
Authors: Sarah A Mbaeyi; Catherine H Bozio; Jonathan Duffy; Lorry G Rubin; Susan Hariri; David S Stephens; Jessica R MacNeil Journal: MMWR Recomm Rep Date: 2020-09-25
Authors: Helen S Marshall; Mark McMillan; Ann Koehler; Andrew Lawrence; Jenny MacLennan; Martin Maiden; Mary Ramsay; Shamez N Ladhani; Caroline Trotter; Ray Borrow; Adam Finn; Thomas Sullivan; Peter Richmond; Charlene Kahler; Jane Whelan; Kumaran Vadivelu Journal: BMJ Open Date: 2019-05-06 Impact factor: 2.692
Authors: Luke R Green; Neelam Dave; Adeolu B Adewoye; Jay Lucidarme; Stephen A Clark; Neil J Oldfield; David P J Turner; Ray Borrow; Christopher D Bayliss Journal: J Infect Dis Date: 2019-08-30 Impact factor: 5.226
Authors: Jonathan C Holmes; Luke R Green; Neil J Oldfield; David P J Turner; Christopher D Bayliss Journal: Front Genet Date: 2020-12-07 Impact factor: 4.599
Authors: Melissa J Whaley; Jeni T Vuong; Nadav Topaz; How-Yi Chang; Jennifer Dolan Thomas; Laurel T Jenkins; Fang Hu; Susanna Schmink; Evelene Steward-Clark; Marsenia Mathis; Lorraine D Rodriguez-Rivera; Adam C Retchless; Sandeep J Joseph; Alexander Chen; Anna M Acosta; Lucy McNamara; Heidi M Soeters; Sarah Mbaeyi; Henju Marjuki; Xin Wang Journal: Front Microbiol Date: 2022-02-17 Impact factor: 5.640
Authors: Jeremy Carr; Emma Plested; Parvinder Aley; Susana Camara; Kimberly Davis; Jenny M MacLennan; Steve Gray; Saul N Faust; Ray Borrow; Hannah Christensen; Caroline Trotter; Martin C J Maiden; Adam Finn; Matthew D Snape Journal: BMJ Open Date: 2020-10-22 Impact factor: 2.692