Miranda van Lunteren1, Zineb Ez-Zaitouni1, Camilla Fongen2, Robert Landewé3,4, Roberta Ramonda5, Désirée van der Heijde1, Floris A van Gaalen1. 1. Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands. 2. Department of Rheumatology, Diakonhjemmet Hospital, Norwegian National Advisory Unit on Rehabilitation in Rheumatology, Oslo, Norway. 3. Amsterdam Rheumatology & Immunology Center, Amsterdam. 4. Department of Rheumatology, Zuyderland Medical Center, Heerlen, The Netherlands. 5. Rheumatology Unit, Department of Medicine DIMED, University of Padova, Padova, Italy.
Abstract
Objectives: To assess if a change in disease activity is associated with a change in work productivity loss (WPL) over 1 year in early axial SpA (axSpA) patients. Methods: Baseline and 1 year data of axSpA patients in the SPondyloArthritis Caught Early cohort were analysed. Linear regression models were built explaining the change in the Ankylosing Spondylitis Disease Activity Score (ASDAS) over time by the change in absenteeism, presenteeism, WPL and activity impairment over time. Effect modification and confounding were tested for age, gender, arm of Assessment of SpondyloArthritis international Society classification criteria, HLA-B27, duration of chronic back pain, profession and medication. Results: At baseline, in 105 axSpA patients (48% female, mean age 30.8 years, mean symptom duration 13.6 months, 92% HLA-B27 positive, 24% radiographic sacroiliitis), the mean ASDAS was 2.4 (s.d. 1.0), absenteeism 9% (s.d. 23), presenteeism 33% (s.d. 28), WPL 36% (s.d. 30) and activity impairment 37% (s.d. 25). After 1 year, the mean ASDAS decreased to 2.0 (s.d. 0.8) and absenteeism, presenteeism, WPL and activity impairment improved to 6% (s.d. 22), 26% (s.d. 26), 27% (s.d. 29) and 27% (s.d. 26), respectively. Models showed that if ASDAS decreased 1 unit, absenteeism, presenteeism, WPL and activity impairment improved by 5, 17, 16 and 18%, respectively. The impact of disease activity on work productivity was higher in patients with shorter symptom duration and the impact on absenteeism was higher in patients starting pharmacological treatment. Conclusions: In early axSpA patients, work productivity and daily activities are seriously impacted at baseline and 1 year. However, decreasing disease activity is associated with marked improvements in work productivity and daily activities.
Objectives: To assess if a change in disease activity is associated with a change in work productivity loss (WPL) over 1 year in early axial SpA (axSpA) patients. Methods: Baseline and 1 year data of axSpApatients in the SPondyloArthritis Caught Early cohort were analysed. Linear regression models were built explaining the change in the Ankylosing Spondylitis Disease Activity Score (ASDAS) over time by the change in absenteeism, presenteeism, WPL and activity impairment over time. Effect modification and confounding were tested for age, gender, arm of Assessment of SpondyloArthritis international Society classification criteria, HLA-B27, duration of chronic back pain, profession and medication. Results: At baseline, in 105 axSpApatients (48% female, mean age 30.8 years, mean symptom duration 13.6 months, 92% HLA-B27 positive, 24% radiographic sacroiliitis), the mean ASDAS was 2.4 (s.d. 1.0), absenteeism 9% (s.d. 23), presenteeism 33% (s.d. 28), WPL 36% (s.d. 30) and activity impairment 37% (s.d. 25). After 1 year, the mean ASDAS decreased to 2.0 (s.d. 0.8) and absenteeism, presenteeism, WPL and activity impairment improved to 6% (s.d. 22), 26% (s.d. 26), 27% (s.d. 29) and 27% (s.d. 26), respectively. Models showed that if ASDAS decreased 1 unit, absenteeism, presenteeism, WPL and activity impairment improved by 5, 17, 16 and 18%, respectively. The impact of disease activity on work productivity was higher in patients with shorter symptom duration and the impact on absenteeism was higher in patients starting pharmacological treatment. Conclusions: In early axSpApatients, work productivity and daily activities are seriously impacted at baseline and 1 year. However, decreasing disease activity is associated with marked improvements in work productivity and daily activities.
Authors: Mark Alan Fontana; Wasif Islam; Michelle A Richardson; Cathlyn K Medina; Eleni C Kohilakis; Sheeraz A Qureshi; Catherine H MacLean Journal: Spine J Date: 2021-10-24 Impact factor: 4.297
Authors: Mary Lucy Marques; Alessia Alunno; Sofia Ramiro; Polina Putrik; Annelies Boonen; Marieke M Ter Wee; Louise Falzon Journal: RMD Open Date: 2021-02
Authors: Steven L Truong; Tim McEwan; Paul Bird; Irwin Lim; Nivene F Saad; Lionel Schachna; Andrew L Taylor; Philip C Robinson Journal: Rheumatol Ther Date: 2021-12-28
Authors: Elena Nikiphorou; Pedro D Carvalho; Annelies Boonen; Bruno Fautrel; Pascal Richette; Pedro M Machado; Desirée van der Heijde; Robert Landewé; Sofia Ramiro Journal: RMD Open Date: 2021-06
Authors: Mark D Russell; Fiona Coath; Mark Yates; Katie Bechman; Sam Norton; James B Galloway; Joanna Ledingham; Raj Sengupta; Karl Gaffney Journal: Rheumatology (Oxford) Date: 2022-02-02 Impact factor: 7.580
Authors: Elena Nikiphorou; Annelies Boonen; Bruno Fautrel; Pascal Richette; Robert Landewé; Désirée van der Heijde; Sofia Ramiro Journal: Rheumatology (Oxford) Date: 2022-05-05 Impact factor: 7.046