Literature DB >> 29153851

APOBEC Enzymes as Targets for Virus and Cancer Therapy.

Margaret E Olson1, Reuben S Harris2, Daniel A Harki3.   

Abstract

Human DNA cytosine-to-uracil deaminases catalyze mutations in both pathogen and cellular genomes. APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H restrict human immunodeficiency virus 1 (HIV-1) infection in cells deficient in the viral infectivity factor (Vif), and have the potential to catalyze sublethal levels of mutation in viral genomes in Vif-proficient cells. At least two APOBEC3 enzymes, and in particular APOBEC3B, are sources of somatic mutagenesis in cancer cells that drive tumor evolution and may manifest clinically as recurrence, metastasis, and/or therapy resistance. Consequently, APOBEC3 enzymes are tantalizing targets for developing chemical probes and therapeutic molecules to harness mutational processes in human disease. This review highlights recent efforts to chemically manipulate APOBEC3 activities.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  APOBEC; cancer; chemical probes; cytosine-to-uracil; mutation; virus

Mesh：

Substances：

Year:  2017        PMID： 29153851      PMCID： PMC5775913          DOI： 10.1016/j.chembiol.2017.10.007

Source DB:  PubMed          Journal:  Cell Chem Biol        ISSN： 2451-9448            Impact factor:   8.116


  129 in total

1.  An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22.

Authors:  Adam Jarmuz; Ann Chester; Jayne Bayliss; Jane Gisbourne; Ian Dunham; James Scott; Naveenan Navaratnam
Journal:  Genomics       Date:  2002-03       Impact factor: 5.736

2.  New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays.

Authors:  Jonathan B Baell; Georgina A Holloway
Journal:  J Med Chem       Date:  2010-04-08       Impact factor: 7.446

Review 3.  APOBECs and virus restriction.

Authors:  Reuben S Harris; Jaquelin P Dudley
Journal:  Virology       Date:  2015-03-26       Impact factor: 3.616

4.  The APOBEC3C crystal structure and the interface for HIV-1 Vif binding.

Authors:  Shingo Kitamura; Hirotaka Ode; Masaaki Nakashima; Mayumi Imahashi; Yuriko Naganawa; Teppei Kurosawa; Yoshiyuki Yokomaku; Takashi Yamane; Nobuhisa Watanabe; Atsuo Suzuki; Wataru Sugiura; Yasumasa Iwatani
Journal:  Nat Struct Mol Biol       Date:  2012-09-23       Impact factor: 15.369

5.  Multifaceted counter-APOBEC3G mechanisms employed by HIV-1 Vif.

Authors:  Elena Britan-Rosich; Roni Nowarski; Moshe Kotler
Journal:  J Mol Biol       Date:  2011-07-29       Impact factor: 5.469

6.  1.92 Angstrom Zinc-Free APOBEC3F Catalytic Domain Crystal Structure.

Authors:  Nadine M Shaban; Ke Shi; Ming Li; Hideki Aihara; Reuben S Harris
Journal:  J Mol Biol       Date:  2016-04-30       Impact factor: 5.469

7.  Enzymatically active APOBEC3G is required for efficient inhibition of human immunodeficiency virus type 1.

Authors:  Eri Miyagi; Sandrine Opi; Hiroaki Takeuchi; Mohammad Khan; Ritu Goila-Gaur; Sandra Kao; Klaus Strebel
Journal:  J Virol       Date:  2007-10-10       Impact factor: 5.103

8.  Cytidine deamination induced HIV-1 drug resistance.

Authors:  Lubbertus C F Mulder; Ariana Harari; Viviana Simon
Journal:  Proc Natl Acad Sci U S A       Date:  2008-04-07       Impact factor: 11.205

Review 9.  The AID/APOBEC family of nucleic acid mutators.

Authors:  Silvestro G Conticello
Journal:  Genome Biol       Date:  2008-06-17       Impact factor: 13.583

10.  Preclinical in vivo evaluation of the safety of a multi-shRNA-based gene therapy against HIV-1.

Authors:  Mireille Centlivre; Nicolas Legrand; Sofieke Klamer; Ying Poi Liu; Karin Jasmijn von Eije; Martino Bohne; Esther Siteur-van Rijnstra; Kees Weijer; Bianca Blom; Carlijn Voermans; Hergen Spits; Ben Berkhout
Journal:  Mol Ther Nucleic Acids       Date:  2013-09-03       Impact factor: 10.183
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  60 in total

Review 1.  The spectrum of APOBEC3 activity: From anti-viral agents to anti-cancer opportunities.

Authors:  Abby M Green; Matthew D Weitzman
Journal:  DNA Repair (Amst)       Date:  2019-09-13

2.  Determinants of Oligonucleotide Selectivity of APOBEC3B.

Authors:  Jeffrey R Wagner; Özlem Demir; Michael A Carpenter; Hideki Aihara; Daniel A Harki; Reuben S Harris; Rommie E Amaro
Journal:  J Chem Inf Model       Date:  2018-09-10       Impact factor: 4.956

3.  Exploiting Ubiquitin Ligases for Induced Target Degradation as an Antiviral Strategy.

Authors:  Rati Verma
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

Review 4.  Structural perspectives on HIV-1 Vif and APOBEC3 restriction factor interactions.

Authors:  Farshad C Azimi; Jeffrey E Lee
Journal:  Protein Sci       Date:  2019-11-29       Impact factor: 6.725

Review 5.  Modulating protein-protein interaction networks in protein homeostasis.

Authors:  Mengqi Zhong; Gregory M Lee; Eline Sijbesma; Christian Ottmann; Michelle R Arkin
Journal:  Curr Opin Chem Biol       Date:  2019-03-23       Impact factor: 8.822

Review 6.  Unveiling Human Non-Random Genome Editing Mechanisms Activated in Response to Chronic Environmental Changes: I. Where Might These Mechanisms Come from and What Might They Have Led To?

Authors:  Loris Zamai
Journal:  Cells       Date:  2020-10-27       Impact factor: 6.600

7.  A lentivirus-based system for Cas9/gRNA expression and subsequent removal by Cre-mediated recombination.

Authors:  Michael A Carpenter; Emily K Law; Artur Serebrenik; William L Brown; Reuben S Harris
Journal:  Methods       Date:  2018-12-19       Impact factor: 3.608

8.  Small Molecule Inhibitors of Activation-Induced Deaminase Decrease Class Switch Recombination in B Cells.

Authors:  Juan Alvarez-Gonzalez; Adam Yasgar; Robert W Maul; Amanda E Rieffer; Daniel J Crawford; Daniel J Salamango; Dorjbal Dorjsuren; Alexey V Zakharov; Daniel J Jansen; Ganesha Rai; Juan Marugan; Anton Simeonov; Reuben S Harris; Rahul M Kohli; Patricia J Gearhart
Journal:  ACS Pharmacol Transl Sci       Date:  2021-05-07

9.  Targeting Hepatitis B Virus Covalently Closed Circular DNA and Hepatitis B Virus X Protein: Recent Advances and New Approaches.

Authors:  Nicholas A Prescott; Yaron Bram; Robert E Schwartz; Yael David
Journal:  ACS Infect Dis       Date:  2019-09-27       Impact factor: 5.084

10.  APOBEC3F Constitutes a Barrier to Successful Cross-Species Transmission of Simian Immunodeficiency Virus SIVsmm to Humans.

Authors:  Rayhane Nchioua; Dorota Kmiec; Amit Gaba; Christina M Stürzel; Tyson Follack; Stephen Patrick; Andrea Kirmaier; Welkin E Johnson; Beatrice H Hahn; Linda Chelico; Frank Kirchhoff
Journal:  J Virol       Date:  2021-08-10       Impact factor: 5.103
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