Tonje Teigland1, Marjolein M Iversen2, Dag A Sangnes3, Georg Dimcevski3, Eirik Søfteland4. 1. Department of Medicine, Haukeland University Hospital, PO Box 1400, N-5021 Bergen, Norway; Faculty of Health and Social Science, Bergen University College, PO Box 7030, N-5020 Bergen, Norway. 2. Faculty of Health and Social Science, Bergen University College, PO Box 7030, N-5020 Bergen, Norway. 3. Department of Medicine, Haukeland University Hospital, PO Box 1400, N-5021 Bergen, Norway. 4. Department of Medicine, Haukeland University Hospital, PO Box 1400, N-5021 Bergen, Norway; Hormone Laboratory, Haukeland University Hospital, PO Box 1400, N-5021 Bergen, Norway. Electronic address: eirik.wigtil.softeland@helse-bergen.no.
Abstract
AIMS: To examine patient reported outcomes (PRO) in patients previously assessed for diabetic gastroparesis, and to investigate how symptoms of gastroparesis evolve over time. In addition, to further evaluate outcomes in those with versus without diabetic gastroparesis at baseline. METHODS: Thirty-four patients with diabetes and gastrointestinal (GI) symptoms, diagnosed with or without diabetic gastroparesis in 2011-2013, were included in this follow-up study. PRO were measured with the Patient assessment of upper gastrointestinal symptom severity index (PAGI-SYM), 36-Item Short Form Survey (SF-36), Patient assessment of upper gastrointestinal disorders-quality of life (PAGI-QOL) and Hospital Anxiety and Depression Scale (HADS). Demographic factors and clinical variables were also recorded. RESULTS: Participants diagnosed with gastroparesis had improved glycemic control (p=0.04) and less GI symptoms (p=0.001), after a follow-up time of 3.2years (mean). Both groups reported severely impaired quality of life (QoL). In total 47% reported symptoms of anxiety, 38% symptoms of depression (scores≥8). GI symptom severity or other PRO could not differentiate between the two groups. CONCLUSIONS: Patients diagnosed with diabetic gastroparesis, as well as those with gastroparesis symptoms - but normal gastric emptying, suffer from severely impaired QoL and a high burden of anxiety and depressive symptoms.
AIMS: To examine patient reported outcomes (PRO) in patients previously assessed for diabetic gastroparesis, and to investigate how symptoms of gastroparesis evolve over time. In addition, to further evaluate outcomes in those with versus without diabetic gastroparesis at baseline. METHODS: Thirty-four patients with diabetes and gastrointestinal (GI) symptoms, diagnosed with or without diabetic gastroparesis in 2011-2013, were included in this follow-up study. PRO were measured with the Patient assessment of upper gastrointestinal symptom severity index (PAGI-SYM), 36-Item Short Form Survey (SF-36), Patient assessment of upper gastrointestinal disorders-quality of life (PAGI-QOL) and Hospital Anxiety and Depression Scale (HADS). Demographic factors and clinical variables were also recorded. RESULTS:Participants diagnosed with gastroparesis had improved glycemic control (p=0.04) and less GI symptoms (p=0.001), after a follow-up time of 3.2years (mean). Both groups reported severely impaired quality of life (QoL). In total 47% reported symptoms of anxiety, 38% symptoms of depression (scores≥8). GI symptom severity or other PRO could not differentiate between the two groups. CONCLUSIONS:Patients diagnosed with diabetic gastroparesis, as well as those with gastroparesis symptoms - but normal gastric emptying, suffer from severely impaired QoL and a high burden of anxiety and depressive symptoms.
Authors: Mattis Bekkelund; Dag A Sangnes; Eirik Søfteland; Lars Aabakken; Martin Biermann; Elisabeth K Steinsvik; Trygve Hausken; Georg Dimcevski; Jan Gunnar Hatlebakk Journal: Clin Exp Gastroenterol Date: 2021-04-28
Authors: Dag A Sangnes; Katarina Lundervold; Mattis Bekkelund; Hilde L von Volkmann; Birgitte Berentsen; Odd Helge Gilja; Georg Dimcevski; Eirik Søfteland Journal: United European Gastroenterol J Date: 2021-10-23 Impact factor: 4.623