Emily W Harville1, Markus Juonala2, Jorma S A Viikari3, Mika Kähönen4, Olli T Raitakari5. 1. Department of Epidemiology, Tulane University School of Public Health, USA. Electronic address: Harville@tulane.edu. 2. Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland; Murdoch Childrens Research Institute, Parkville, Victoria, Australia. 3. Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland. 4. Department of Clinical Psychology, Tampere University Hospital and University of Tampere, Finland. 5. The Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Department of Clinical Physiology, Turku University Hospital, Finland.
Abstract
OBJECTIVES: Pregnancy complications predict or even predispose to later cardiovascular disease in the mother. We examined whether pregnancy complications are associated with post-pregnancy measures of endothelial dysfunction and arterial stiffness. STUDY DESIGN: Prospective cohort; Data for 847 women female participants in the Cardiovascular Risk in Young Finns study were linked with the national birth registry. Preterm birth (<37weeks), low birthweight (<2500g), small-for-gestational-age (weight <10th percentile for gestational age), and hypertensive disorders of pregnancy were examined as predictors of later vascular measures. MAIN OUTCOME MEASURES: Flow-mediated dilatation (FMD), carotid intima-media thickness (IMT), Young's elastic modulus (YEM), and carotid artery distensibility. RESULTS: In some analyses, gestational hypertension and pre-eclampsia were associated with increased YEM. Low birthweight was also associated with an increase in IMT, and this increased risk was present prior to the pregnancy. CONCLUSIONS: The increased cardiovascular risk in the mother observed after low birthweight and hypertensive disorders may be due to vascular changes, and some of this increased risk may be present before pregnancy.
OBJECTIVES: Pregnancy complications predict or even predispose to later cardiovascular disease in the mother. We examined whether pregnancy complications are associated with post-pregnancy measures of endothelial dysfunction and arterial stiffness. STUDY DESIGN: Prospective cohort; Data for 847 women female participants in the Cardiovascular Risk in Young Finns study were linked with the national birth registry. Preterm birth (<37weeks), low birthweight (<2500g), small-for-gestational-age (weight <10th percentile for gestational age), and hypertensive disorders of pregnancy were examined as predictors of later vascular measures. MAIN OUTCOME MEASURES: Flow-mediated dilatation (FMD), carotid intima-media thickness (IMT), Young's elastic modulus (YEM), and carotid artery distensibility. RESULTS: In some analyses, gestational hypertension and pre-eclampsia were associated with increased YEM. Low birthweight was also associated with an increase in IMT, and this increased risk was present prior to the pregnancy. CONCLUSIONS: The increased cardiovascular risk in the mother observed after low birthweight and hypertensive disorders may be due to vascular changes, and some of this increased risk may be present before pregnancy.
Authors: Olli T Raitakari; Markus Juonala; Tapani Rönnemaa; Liisa Keltikangas-Järvinen; Leena Räsänen; Matti Pietikäinen; Nina Hutri-Kähönen; Leena Taittonen; Eero Jokinen; Jukka Marniemi; Antti Jula; Risto Telama; Mika Kähönen; Terho Lehtimäki; Hans K Akerblom; Jorma S A Viikari Journal: Int J Epidemiol Date: 2008-02-08 Impact factor: 7.196
Authors: Marietta Charakida; Stefano Masi; Thomas F Lüscher; John J P Kastelein; John E Deanfield Journal: Eur Heart J Date: 2010-09-23 Impact factor: 29.983
Authors: Yoav Yinon; John C P Kingdom; Ayodele Odutayo; Rahim Moineddin; Sascha Drewlo; Vesta Lai; David Z I Cherney; Michelle A Hladunewich Journal: Circulation Date: 2010-10-18 Impact factor: 29.690
Authors: D S Celermajer; K E Sorensen; V M Gooch; D J Spiegelhalter; O I Miller; I D Sullivan; J K Lloyd; J E Deanfield Journal: Lancet Date: 1992-11-07 Impact factor: 79.321