| Literature DB >> 29153613 |
Bárbara Leal1, João Chaves2, Cláudia Carvalho3, Rui Rangel4, Agostinho Santos5, Andreia Bettencourt3, João Lopes6, João Ramalheira6, Berta M Silva3, António Martins da Silva7, Paulo P Costa8.
Abstract
Neuroinflammation may be central in epileptogenesis. In this study we analysed inflammatory reaction markers in brain tissue of Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis (MTLE-HS) patients. TLR4, IL-1β and IL-10 gene expression as well as the presence of activated HLA-DR+ microglia was evaluated in 23 patients and 10 cadaveric controls. Inflammation characterized by the presence of HLA-DR+ microglia and TLR4, IL-1β overexpression was evident in hippocampus and anterior temporal cortex of MTLE-HS patients. Anti-inflammatory IL-10 was also overexpressed in MTLE-HS patients. Our results show that hippocampal neuroinflammation extends beyond lesional limits, as far as the anterior temporal cortex.Entities:
Keywords: Activated microglia; Cytokines; Epilepsy; Hippocampus; Inflammation
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Year: 2017 PMID： 29153613 DOI： 10.1016/j.jneuroim.2017.10.014
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478