| Literature DB >> 29153546 |
Linda Rolf1, Anne-Hilde Muris2, Ruud Theunissen3, Raymond Hupperts4, Jan Damoiseaux5, Joost Smolders6.
Abstract
Vitamin D3 upregulates IL-2 receptor alpha (IL2RA, CD25)-expression on CD4+ T cells in vitro. We investigated effects of 48-weeks vitamin D3 supplements on CD25-expression by CD4+ T cells of patients with multiple sclerosis (MS). There was no significant difference between the vitamin D3 (n=30) and placebo group (n=23) in IL2RA mRNA-expression by PBMC. Likewise, CD25 cell surface-expression by conventional or regulatory T cells (Treg) did not differ between groups, although Treg CD25-expression and circulating soluble-CD25 levels decreased significantly in the placebo but not vitamin D3-group. We speculate that vitamin D3 may promote the maintenance of CD25-related immune homeostasis in MS.Entities:
Keywords: CD25; IL-2 receptor; Multiple sclerosis; Regulatory T cell; T cell; Vitamin D
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Year: 2017 PMID： 29153546 DOI： 10.1016/j.jneuroim.2017.11.007
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478