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Literature DB >> 29152011

Massively parallel simulations of hemodynamics in the primary large arteries of the human vasculature.

Amanda Randles¹, Erik W Draeger¹, Peter E Bailey².

Abstract

We present a computational model of three-dimensional and unsteady hemodynamics within the primary large arteries in the human on 1,572,864 cores of the IBM Blue Gene/Q. Models of large regions of the circulatory system are needed to study the impact of local factors on global hemodynamics and to inform next generation drug delivery mechanisms. The HARVEY code successfully addresses key challenges that can hinder effective solution of image-based hemodynamics on contemporary supercomputers, such as limited memory capacity and bandwidth, flexible load balancing, and scalability. This work is the first demonstration of large fluid dynamics simulations of the aortofemoral region of the circulatory system at resolutions as small as 10 μm.

Entities: Chemical Disease Species

Keywords: Computational fluid dynamics; High performance computing; Lattice Boltzmann; Patient-specific hemodynamics; Strong scaling

Year: 2015 PMID： 29152011 PMCID： PMC5693253 DOI： 10.1016/j.jocs.2015.04.003

Source DB: PubMed Journal: J Comput Sci

11 in total

1. Computer simulation of arterial flow with applications to arterial and aortic stenoses.

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Journal: J Biomech Date: 1992-12 Impact factor: 2.712

2. Use of the Boltzmann equation to simulate lattice gas automata.

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3. Signed distance computation using the angle weighted pseudonormal.

Authors: J Andreas Baerentzen; Henrik Aanaes
Journal: IEEE Trans Vis Comput Graph Date: 2005 May-Jun Impact factor: 4.579

4. Analog studies of the human systemic arterial tree.

Authors: N Westerhof; F Bosman; C J De Vries; A Noordergraaf
Journal: J Biomech Date: 1969-05 Impact factor: 2.712

5. The application of multiscale modelling to the process of development and prevention of stenosis in a stented coronary artery.

Authors: D J W Evans; P V Lawford; J Gunn; D Walker; D R Hose; R H Smallwood; B Chopard; M Krafczyk; J Bernsdorf; A Hoekstra
Journal: Philos Trans A Math Phys Eng Sci Date: 2008-09-28 Impact factor: 4.226

6. Characterization of cerebral aneurysms for assessing risk of rupture by using patient-specific computational hemodynamics models.

Authors: Juan R Cebral; Marcelo A Castro; James E Burgess; Richard S Pergolizzi; Michael J Sheridan; Christopher M Putman
Journal: AJNR Am J Neuroradiol Date: 2005 Nov-Dec Impact factor: 3.825

7. Effects of hematocrit and plasma proteins on human blood rheology at low shear rates.

Authors: S Chien; S Usami; H M Taylor; J L Lundberg; M I Gregersen
Journal: J Appl Physiol Date: 1966-01 Impact factor: 3.531

8. Multi-Scale Computational Model of Three-Dimensional Hemodynamics within a Deformable Full-Body Arterial Network.

Authors: Nan Xiao; Jay D Humphrey; C Alberto Figueroa
Journal: J Comput Phys Date: 2013-07-01 Impact factor: 3.553

9. Pulse wave propagation in a model human arterial network: Assessment of 1-D visco-elastic simulations against in vitro measurements.

Authors: Jordi Alastruey; Ashraf W Khir; Koen S Matthys; Patrick Segers; Spencer J Sherwin; Pascal R Verdonck; Kim H Parker; Joaquim Peiró
Journal: J Biomech Date: 2011-07-02 Impact factor: 2.712

Massively parallel simulations of hemodynamics in the primary large arteries of the human vasculature.

1. Computer simulation of arterial flow with applications to arterial and aortic stenoses.

2. Use of the Boltzmann equation to simulate lattice gas automata.

3. Signed distance computation using the angle weighted pseudonormal.

4. Analog studies of the human systemic arterial tree.

5. The application of multiscale modelling to the process of development and prevention of stenosis in a stented coronary artery.

6. Characterization of cerebral aneurysms for assessing risk of rupture by using patient-specific computational hemodynamics models.

7. Effects of hematocrit and plasma proteins on human blood rheology at low shear rates.

8. Multi-Scale Computational Model of Three-Dimensional Hemodynamics within a Deformable Full-Body Arterial Network.

9. Pulse wave propagation in a model human arterial network: Assessment of 1-D visco-elastic simulations against in vitro measurements.

10. Toward large-scale computational fluid-solid-growth models of intracranial aneurysms.

1. Does the degree of coarctation of the aorta influence wall shear stress focal heterogeneity?

2. Numerical simulation of a compound capsule in a constricted microchannel.

3. Developing transmission line equations of oxygen transport for predicting oxygen distribution in the arterial system.

4. Role of deformable cancer cells on wall shear stress-associated-VEGF secretion by endothelium in microvasculature.

5. High fidelity blood flow in a patient-specific arteriovenous fistula.

6. Localization of Rolling and Firm-Adhesive Interactions Between Circulating Tumor Cells and the Microvasculature Wall.

7. Examining metastatic behavior within 3D bioprinted vasculature for the validation of a 3D computational flow model.