Literature DB >> 29150890

Suspended animation: the past, present and future of major cardiothoracic trauma.

Syed Mohiyaddin1, Prakash Nanjaiah2, Ahmed O Saad3, Metesh N Acharya4, Tanveer A Khan5, Rhodri H Davies6, Saeed Ashraf1.   

Abstract

About 50% of the trauma victims die at the scene mostly because of exsanguinating haemorrhage. Most trials of resuscitation fail in face of the ongoing bleeding. Ongoing research/studies to save these victims by inducing rapid hypothermia using cardiopulmonary bypass as an emergency initial measure along with delayed resuscitation show improved outcomes. A comprehensive review of this research and analysis of studies showed that rapid induction of hypothermia within 5 min of cardiac arrest is associated with better survival and improved neurological outcome. This led us to conclude that suspended animation is a lifesaving modality for the treatment of trauma victims, otherwise hurtling towards certain death. This should be integrated into regular clinical practice. The US Food and Drug Administration has given its approval for clinical trials on such an intervention.
© 2017 Royal Australasian College of Surgeons.

Entities:  

Keywords:  exsanguination; massive haemorrhagic; operative intervention of cardiothoracic trauma; resuscitation

Mesh:

Year:  2017        PMID: 29150890     DOI: 10.1111/ans.14313

Source DB:  PubMed          Journal:  ANZ J Surg        ISSN: 1445-1433            Impact factor:   1.872


  3 in total

Review 1.  Cryopreservation of Animals and Cryonics: Current Technical Progress, Difficulties and Possible Research Directions.

Authors:  Marlene Davis Ekpo; George Frimpong Boafo; Suleiman Shafiu Gambo; Yuying Hu; Xiangjian Liu; Jingxian Xie; Songwen Tan
Journal:  Front Vet Sci       Date:  2022-06-09

2.  Hypothermia-Associated Coagulopathy: A Comparison of Viscoelastic Monitoring, Platelet Function, and Real Time Live Confocal Microscopy at Low Blood Temperatures, an in vitro Experimental Study.

Authors:  Bernd Wallner; Bettina Schenk; Martin Hermann; Peter Paal; Markus Falk; Giacomo Strapazzon; Wenjun Z Martini; Hermann Brugger; Dietmar Fries
Journal:  Front Physiol       Date:  2020-07-14       Impact factor: 4.566

Review 3.  Physiological Changes in Subjects Exposed to Accidental Hypothermia: An Update.

Authors:  Lars J Bjertnæs; Torvind O Næsheim; Eirik Reierth; Evgeny V Suborov; Mikhail Y Kirov; Konstantin M Lebedinskii; Torkjel Tveita
Journal:  Front Med (Lausanne)       Date:  2022-02-23
  3 in total

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