Literature DB >> 29149814

Calcium Sensitizers in Cardiac Surgery: Who, When, How and Why?

J L Guerrero Orriach1,2,3, A Ramirez-Fernandez2, J J Escalona-Belmonte2, M Rubio-Navarro2, J Cruz-Manas2.   

Abstract

Inodilators are a heterogeneous group of drugs with vasodilatory and inotropic effects. The cardioprotective effect of levosimendan is multifactorial, but now research on levosimendan is focused on the organ-protective properties of this drug in different settings, the regimen that seems to provide the greatest cardiologic and systemic benefits is early administration of levosimendan. We try to answer four questions in this review, which type of patients need this drug? what is the best time to start with it? and the best way that we could give it and finally the reasons for use it. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

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Keywords:  Levosimendan; calcium sensitizers; cardiac surgery; mechanisms; postconditioning; preconditioning.

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Year:  2018        PMID: 29149814     DOI: 10.2174/1570161115666171116150434

Source DB:  PubMed          Journal:  Curr Vasc Pharmacol        ISSN: 1570-1611            Impact factor:   2.719


  1 in total

1.  Renal and Neurologic Benefit of Levosimendan vs Dobutamine in Patients With Low Cardiac Output Syndrome After Cardiac Surgery: Clinical Trial FIM-BGC-2014-01.

Authors:  Jose L Guerrero-Orriach; Alfredo Malo-Manso; Marta Ramirez-Aliaga; Ana Isabel Florez Vela; Manuel Galán-Ortega; Isabel Moreno-Cortes; Inmaculada Gonzalez-Almendros; Alicia Ramirez-Fernandez; Daniel Ariza-Villanueva; Juan Jose Escalona-Belmonte; Guillermo Quesada-Muñoz; Enrique Sepúlveda-Haro; Salvador Romero-Molina; Inmaculada Bellido-Estevez; Aurelio Gomez-Luque; Manuel Rubio-Navarro; Juan Alcaide-Torres; Concepcion Santiago-Fernandez; Lourdes Garrido-Sanchez; Jose Cruz-Mañas
Journal:  Front Pharmacol       Date:  2020-08-26       Impact factor: 5.810

  1 in total

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