| Literature DB >> 29149727 |
E N Bolbasov1, P V Maryin1, K S Stankevich1, A I Kozelskaya1, E V Shesterikov1, Yu I Khodyrevskaya2, M V Nasonova3, D K Shishkova3, Yu A Kudryavtseva3, Y G Anissimov4, S I Tverdokhlebov5.
Abstract
In this study, we modified the surface of bioresorbable electrospun poly-(l-lactic) acid (PLLA) scaffolds by reactive magnetron sputtering of a titanium target under a nitrogen atmosphere. We examined the influence of the plasma treatment time on the structure and properties of electrospun PLLA scaffolds using SEM, XRF, FTIR, XRD, optical goniometry, and mechanical testing. It was observed that the coating formed did not change physicomechanical properties of electrospun PLLA scaffolds and simultaneously, increased their hydrophilicity. No adverse tissue reaction up to 3 months after subcutaneous implantation of the modified scaffolds was detected in in-vivo rat model. The rate of scaffold replacement by the recipient tissue in-vivo was observed to depend on the plasma treatment time.Entities:
Keywords: Biocompatibility; Electrospun PLLA scaffold; Reactive magnetron sputtering
Mesh：
Substances：
Year: 2017 PMID： 29149727 DOI： 10.1016/j.colsurfb.2017.11.028
Source DB: PubMed Journal: Colloids Surf B Biointerfaces ISSN： 0927-7765 Impact factor: 5.268