Literature DB >> 29149616

Protective effects of proanthocyanidins against cadmium-induced testicular injury through the modification of Nrf2-Keap1 signal path in rats.

Liu He1, Peng Li2, Li-Hui Yu3, Lin Li4, Yi Zhang5, Yang Guo6, Miao Long7, Jian-Bin He8, Shu-Hua Yang9.   

Abstract

The purpose of this study was to evaluate the potential chemoprotective effects of proanthocyanidins (PAs) against cadmium (Cd)-induced oxidative damage of testes via Nrf2-Keap1 signal pathway in rats. Briefly, by using biochemical histological analysis, as well as the real time PCR and western blot approach, oxidative damage in rat testicular tissue was observed after exposure to Cd. In addition, significant down-regulations of mRNA and protein levels of nuclear erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1), γ-glutamyl cysteine synthetase (γ-GCS), glutathione peroxidase (GSH-Px) and quinone oxidoreductase 1 (NQO1), as well as a significant up-regulation of Kelch sample related protein-1 (Keap1) levels in testicular tissue were observed after Cd exposure. Notably, these alterations were reverted back to near normalcy in Cd+PAs group rats. In conclusion, PAs exhibited a significant chemopreventive potential against Cd-induced testicular oxidative damage in rats, possibly through the modification of Nrf2-Keap1 signal path.
Copyright © 2017 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Cadium; Nrf2-Keap1; Oxidative damage; Proanthocyanidins; Signal path; Testes; Wistar rats

Mesh：

Substances：

Year:  2017        PMID： 29149616     DOI： 10.1016/j.etap.2017.11.002

Source DB:  PubMed          Journal:  Environ Toxicol Pharmacol        ISSN： 1382-6689            Impact factor:   4.860


  10 in total

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2.  Protective effects of quercetin supplementation against short-term toxicity of cadmium-induced hematological impairment, hypothyroidism, and testicular disturbances in albino rats.

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Review 4.  Exploring Nrf2 as a therapeutic target in testicular dysfunction.

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5.  Selenium Yeast Alleviates Ochratoxin A-Induced Hepatotoxicity via Modulation of the PI3K/AKT and Nrf2/Keap1 Signaling Pathways in Chickens.

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Journal:  Toxins (Basel)       Date:  2020-02-25       Impact factor: 4.546

6.  Crataegus aronia enhances sperm parameters and preserves testicular architecture in both control and non-alcoholic fatty liver disease-induced rats.

Authors:  Mohammad Dallak
Journal:  Pharm Biol       Date:  2018-12       Impact factor: 3.503

7.  Piceatannol inhibits oxidative stress through modification of Nrf2-signaling pathway in testes and attenuates spermatogenesis and steroidogenesis in rats exposed to cadmium during adulthood.

Authors:  Xiaoxue Shi; Lijie Fu
Journal:  Drug Des Devel Ther       Date:  2019-08-13       Impact factor: 4.162

8.  Protective Effect of Astaxanthin on Ochratoxin A-Induced Kidney Injury to Mice by Regulating Oxidative Stress-Related NRF2/KEAP1 Pathway.

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Journal:  Molecules       Date:  2020-03-18       Impact factor: 4.411

9.  Carnosic Acid Attenuates Cadmium Induced Nephrotoxicity by Inhibiting Oxidative Stress, Promoting Nrf2/HO-1 Signalling and Impairing TGF-β1/Smad/Collagen IV Signalling.

Authors:  Sonjit Das; Saikat Dewanjee; Tarun K Dua; Swarnalata Joardar; Pratik Chakraborty; Shovonlal Bhowmick; Achintya Saha; Simanta Bhattacharjee; Vincenzo De Feo
Journal:  Molecules       Date:  2019-11-18       Impact factor: 4.411

10.  Activated Nrf-2 Pathway by Vitamin E to Attenuate Testicular Injuries of Rats with Sub-chronic Cadmium Exposure.

Authors:  Zhuo Chen; Zhicai Zuo; Kejie Chen; Zhuangzhi Yang; Fengyuan Wang; Jing Fang; Hengmin Cui; Hongrui Guo; Ping Ouyang; Zhengli Chen; Chao Huang; Yi Geng; Wentao Liu; Huidan Deng
Journal:  Biol Trace Elem Res       Date:  2021-06-25       Impact factor: 3.738
  10 in total

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