Chuan Zhang1,2,3, Xiaodong Wang3,4, Dan Liu1,2,3, Lingli Zhang1,2,3, Xin Sun5. 1. Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, China. 2. Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, China. 3. Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. 4. Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China. 5. Chinese Evidence-Based Medicine Centre, West China Hospital, Sichuan University, Chengdu, China.
Abstract
BACKGROUND: Pregnant women were identified as a population of priority for vaccination during the H1N1 influenza pandemic outbreak in 2009. OBJECTIVES: To assess adverse fetal outcomes following the administration of H1N1 pandemic vaccination during pregnancy. SEARCH STRATEGY: PubMed, Embase, and Cochrane Library were searched up to January 2017. SELECTION CRITERIA: Cohort studies investigating fetal outcomes after H1N1 influenza vaccination during pregnancy were eligible. The language was limited to English. DATA COLLECTION AND ANALYSIS: Pairs of reviewers independently screened studies for eligibility, assessed the risk of bias, and extracted data from the included studies. MAIN RESULTS: A total of 19 cohort studies were eligible. The use of vaccines during any period of pregnancy was associated with lower risk of stillbirth (adjusted hazard ratio 0.80, 95% confidence interval 0.69-0.92). No significant differences were found between the vaccinated versus unvaccinated groups in terms of the risks of spontaneous abortion, premature birth, and small for gestational age. CONCLUSIONS: The administration of H1N1 vaccines during pregnancy might reduce the risk of stillbirth, a complication associated with H1N1 infection. The quality of evidence was, however, not adequate to reach a definitive conclusion.
BACKGROUND: Pregnant women were identified as a population of priority for vaccination during the H1N1 influenza pandemic outbreak in 2009. OBJECTIVES: To assess adverse fetal outcomes following the administration of H1N1 pandemic vaccination during pregnancy. SEARCH STRATEGY: PubMed, Embase, and Cochrane Library were searched up to January 2017. SELECTION CRITERIA: Cohort studies investigating fetal outcomes after H1N1 influenza vaccination during pregnancy were eligible. The language was limited to English. DATA COLLECTION AND ANALYSIS: Pairs of reviewers independently screened studies for eligibility, assessed the risk of bias, and extracted data from the included studies. MAIN RESULTS: A total of 19 cohort studies were eligible. The use of vaccines during any period of pregnancy was associated with lower risk of stillbirth (adjusted hazard ratio 0.80, 95% confidence interval 0.69-0.92). No significant differences were found between the vaccinated versus unvaccinated groups in terms of the risks of spontaneous abortion, premature birth, and small for gestational age. CONCLUSIONS: The administration of H1N1 vaccines during pregnancy might reduce the risk of stillbirth, a complication associated with H1N1infection. The quality of evidence was, however, not adequate to reach a definitive conclusion.
Authors: Agustín Ciapponi; Ariel Bardach; Agustina Mazzoni; Tomás Alconada; Steven A Anderson; Fernando J Argento; Jamile Ballivian; Karin Bok; Daniel Comandé; Emily Erbelding; Erin Goucher; Beate Kampmann; Ruth Karron; Flor M Munoz; María Carolina Palermo; Edward P K Parker; Federico Rodriguez Cairoli; Victoria Santa María; Andy S Stergachis; Gerald Voss; Xu Xiong; Natalia Zamora; Sabra Zaraa; Mabel Berrueta; Pierre M Buekens Journal: Vaccine Date: 2021-08-13 Impact factor: 3.641
Authors: Agustín Ciapponi; Ariel Bardach; Agustina Mazzoni; Tomás Alconada; Steven Anderson; Fernando J Argento; Jamile Ballivian; Karin Bok; Daniel Comandé; Emily Erbelding; Erin Goucher; Beate Kampmann; Ruth Karron; Flor M Munoz; María Carolina Palermo; Edward P K Parker; Federico Rodriguez Cairoli; María Victoria Santa; Andy Stergachis; Gerald Voss; Xu Xiong; Natalia Zamora; Sabra Zaraa; Mabel Berrueta; Pierre M Buekens Journal: medRxiv Date: 2021-06-06
Authors: James G Donahue; Burney A Kieke; Jennifer P King; Maria A Mascola; Tom T Shimabukuro; Frank DeStefano; Kayla E Hanson; David L McClure; Oluwatosin Olaiya; Jason M Glanz; Rulin C Hechter; Stephanie A Irving; Lisa A Jackson; Nicola P Klein; Allison L Naleway; Eric S Weintraub; Edward A Belongia Journal: Vaccine Date: 2019-09-17 Impact factor: 3.641