Literature DB >> 2914898

Purification and characterization of two classes of neurotoxins from the funnel web spider, Agelenopsis aperta.

W S Skinner1, M E Adams, G B Quistad, H Kataoka, B J Cesarin, F E Enderlin, D A Schooley.   

Abstract

Two classes of paralytic toxins were isolated from the venom of Agelenopsis aperta and their chemical and larvicidal properties characterized. Five acylpolyamine toxins (alpha-agatoxins) of molecular masses 452, 488, 489, 504, and 505 Da produce immediate but reversible paralysis in Manduca sexta following injection. Six insecticidal peptides (mu-agatoxins) produce a gradual but irreversible paralysis. The complete amino acid sequences (36-38 residues) of the mu-agatoxins are presented. These peptides contain eight half-cystines and are quite similar in sequence. At least four of these toxins are amidated at the carboxyl terminus. The secondary structure of one of these toxins (mu-Aga V) was investigated.

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Year:  1989        PMID： 2914898

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  18 in total

1.  Unique bell-shaped voltage-dependent modulation of Na+ channel gating by novel insect-selective toxins from the spider Agelena orientalis.

Authors:  Bert Billen; Alexander Vassilevski; Anton Nikolsky; Sarah Debaveye; Jan Tytgat; Eugene Grishin
Journal:  J Biol Chem       Date:  2010-04-12       Impact factor: 5.157

2.  Neurotoxic acylpolyamines from spider venoms.

Authors:  K D McCormick; J Meinwald
Journal:  J Chem Ecol       Date:  1993-10       Impact factor: 2.626

3.  Structure of membrane-active toxin from crab spider Heriaeus melloteei suggests parallel evolution of sodium channel gating modifiers in Araneomorphae and Mygalomorphae.

Authors:  Antonina A Berkut; Steve Peigneur; Mikhail Yu Myshkin; Alexander S Paramonov; Ekaterina N Lyukmanova; Alexander S Arseniev; Eugene V Grishin; Jan Tytgat; Zakhar O Shenkarev; Alexander A Vassilevski
Journal:  J Biol Chem       Date:  2014-10-28       Impact factor: 5.157

4.  The solution structure of omega-Aga-IVB, a P-type calcium channel antagonist from venom of the funnel web spider, Agelenopsis aperta.

Authors:  M D Reily; V Thanabal; M E Adams
Journal:  J Biomol NMR       Date:  1995-02       Impact factor: 2.835

5.  Structural and Functional Diversity of Peptide Toxins from Tarantula Haplopelma hainanum (Ornithoctonus hainana) Venom Revealed by Transcriptomic, Peptidomic, and Patch Clamp Approaches.

Authors:  Yi-Ya Zhang; Yong Huang; Quan-Ze He; Ji Luo; Li Zhu; Shan-Shan Lu; Jin-Yan Liu; Peng-Fei Huang; Xiong-Zhi Zeng; Song-Ping Liang
Journal:  J Biol Chem       Date:  2015-03-13       Impact factor: 5.157

6.  Two classes of channel-specific toxins from funnel web spider venom.

Authors:  M E Adams; E E Herold; V J Venema
Journal:  J Comp Physiol A       Date:  1989-01       Impact factor: 1.836

7.  Biochemical and pharmacological studies on a lethal neurotoxic polypeptide from Phoneutria nigriventer spider venom.

Authors:  L R Troncone; I Lebrun; F Magnoli; T Yamane
Journal:  Neurochem Res       Date:  1995-07       Impact factor: 3.996

8.  Multiple transcriptome mining coupled with tissue specific molecular cloning and mass spectrometry provide insights into agatoxin-like peptide conservation in decapod crustaceans.

Authors:  Andrew E Christie; Cindy D Rivera; Catherine M Call; Patsy S Dickinson; Elizabeth A Stemmler; J Joe Hull
Journal:  Gen Comp Endocrinol       Date:  2020-09-09       Impact factor: 2.822

9.  Proton nuclear magnetic resonance studies on huwentoxin-I from the venom of the spider Selenocosmia huwena: 1. Sequence-specific 1H-NMR assignments.

Authors:  Y Qu; S Liang; J Ding; L Ma; R Zhang; X Gu
Journal:  J Protein Chem       Date:  1995-10

10.  Assignment of the three disulfide bridges of huwentoxin-I, a neurotoxin from the spider selenocosmia huwena.

Authors:  D Zhang; S Liang
Journal:  J Protein Chem       Date:  1993-12
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