John G Laffey1,2,3, Cheryl Misak4, Brian P Kavanagh2,5. 1. Departments of Anesthesia and Critical Care Medicine, Critical Illness and Injury Research Centre, Keenan Research Centre for Biomedical Science, St Michael's Hospital, Toronto, Canada john.laffey@nuigalway.ie. 2. Departments of Anesthesia, Physiology and Interdepartmental Division of Critical Care Medicine, University of Toronto, Canada. 3. Anaesthesia, School of Medicine, National University of Ireland, Galway, Ireland. 4. Department of Philosophy, University of Toronto, Canada. 5. Department of Critical Care Medicine and Anesthesia, Hospital for Sick Children, Toronto, Canada.