Yasuhiko Nakao1, Satoru Hashimoto2, Seigo Abiru1, Atsumasa Komori1, Kazumi Yamasaki1, Shinya Nagaoka1, Akira Saeki1, Shigemune Bekki1, Yuki Kugiyama1, Tamotsu Kuroki1, Masahiro Ito1, Kazuhiko Nakao3, Hiroshi Yatsuhashi4. 1. Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. 2. Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. 3. Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. 4. Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. Electronic address: yatsuhashi@nagasaki-mc.com.