Literature DB >> 2914605

One of two subunits of masking protein in latent TGF-beta is a part of pro-TGF-beta.

F Okada1, K Yamaguchi, A Ichihara, T Nakamura.   

Abstract

A high molecular mass latent form of transforming growth factor type-beta (TGF-beta) was purified to homogeneity from rat platelets by a seven-step procedure involving group-specific affinity chromatographies on Red-Toyopearl and zinc chelating-Sepharose. The purified latent TGF-beta was a complex of TGF-beta (25 kDa) and the binding protein previously named masking protein (approximately 400 kDa) [(1986) Biochem. Biophys. Res. Commun. 141, 176-184]. Analysis of the peptide structure by gel electrophoresis showed that the masking protein consisted of two subunits of 39 kDa and 105-120 kDa linked by disulfide bonds. N-terminal amino-acid sequencing of the 39 kDa subunit indicated that this subunit was identical to the N-terminal part of the TGF-beta precursor.

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Year:  1989        PMID： 2914605     DOI： 10.1016/0014-5793(89)80477-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

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Authors:  D E Mosedale; D J Grainger
Journal:  Biochem J       Date:  1999-10-01       Impact factor: 3.857

2.  Mechanisms controlling growth of hepatocytes in primary culture.

Authors:  A Ichihara
Journal:  Dig Dis Sci       Date:  1991-04       Impact factor: 3.199

3.  Stimulation of rat endothelial cell transforming growth factor-beta production by bleomycin.

Authors:  S H Phan; M Gharaee-Kermani; F Wolber; U S Ryan
Journal:  J Clin Invest       Date:  1991-01       Impact factor: 14.808

4.  Transforming growth factor-beta production in anti-glomerular basement membrane disease in the rabbit.

Authors:  T Coimbra; R Wiggins; J W Noh; S Merritt; S H Phan
Journal:  Am J Pathol       Date:  1991-01       Impact factor: 4.307

5.  Fibronectin is the major fibroblast chemoattractant in rabbit anti-glomerular basement membrane disease.

Authors:  M Gharaee-Kermani; R Wiggins; F Wolber; M Goyal; S H Phan
Journal:  Am J Pathol       Date:  1996-03       Impact factor: 4.307

6.  Molecular cloning of the large subunit of transforming growth factor type beta masking protein and expression of the mRNA in various rat tissues.

Authors:  T Tsuji; F Okada; K Yamaguchi; T Nakamura
Journal:  Proc Natl Acad Sci U S A       Date:  1990-11       Impact factor: 11.205

7.  Evidence for the involvement of dietary lipids on the modulation of transforming growth factor-beta1 in the platelets of male rats.

Authors:  J M Adam; J Raju; N Khalil; R P Bird
Journal:  Mol Cell Biochem       Date:  2000-08       Impact factor: 3.396

8.  Differential tubulogenic and branching morphogenetic activities of growth factors: implications for epithelial tissue development.

Authors:  E J Barros; O F Santos; K Matsumoto; T Nakamura; S K Nigam
Journal:  Proc Natl Acad Sci U S A       Date:  1995-05-09       Impact factor: 11.205

9.  Differential modulation of transforming growth factor-betas and cyclooxygenases in the platelet lysates of male F344 rats by dietary lipids and piroxicam.

Authors:  Jayadev Raju; Ranjana P Bird
Journal:  Mol Cell Biochem       Date:  2002-02       Impact factor: 3.396

10.  OP-1 cDNA encodes an osteogenic protein in the TGF-beta family.

Authors:  E Ozkaynak; D C Rueger; E A Drier; C Corbett; R J Ridge; T K Sampath; H Oppermann
Journal:  EMBO J       Date:  1990-07       Impact factor: 11.598
  10 in total

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