Siti Setiati1, Jane E Fransiska1, Tirza Z Tamin2, Rahmi Istanti1. 1. Faculty of Medicine, Department of Internal Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia. 2. Faculty of Medicine, Department of Medical Rehabilitation, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Abstract
AIM: To determine the effect of alfacalcidol on muscle strength and functional mobility in Indonesian older women whose handgrip strength was low. METHODS: A randomized, double-blind controlled trial was carried out among 95 older women whose handgrip strength was ≤22 kg. Participants were randomized into two groups: 47 participants received alfacalcidol 0.5 μg/day and 48 participants received a placebo. Each participant in both groups was given calcium 500 mg/day. Handgrip strength as well as the Timed-Up and Go test were measured before and after 90 days of intervention. Per protocol analysis after intervention between two groups was carried out. RESULTS: There was a significant improvement of handgrip strength in the group that received alfacalcidol compared with the placebo group (15.50 vs 13.75; P = 0.003). The median time for the Timed-Up and Go test in the alfacalcidol group also improved significantly compared with the placebo group (9.01 vs 10.07, P = 0.028). CONCLUSIONS:Alfacalcidol with daily doses of 0.5 μg significantly improved muscle strength and functional mobility in Indonesian older women. Geriatr Gerontol Int 2018; 18: 434-440.
RCT Entities:
AIM: To determine the effect of alfacalcidol on muscle strength and functional mobility in Indonesian older women whose handgrip strength was low. METHODS: A randomized, double-blind controlled trial was carried out among 95 older women whose handgrip strength was ≤22 kg. Participants were randomized into two groups: 47 participants received alfacalcidol 0.5 μg/day and 48 participants received a placebo. Each participant in both groups was given calcium 500 mg/day. Handgrip strength as well as the Timed-Up and Go test were measured before and after 90 days of intervention. Per protocol analysis after intervention between two groups was carried out. RESULTS: There was a significant improvement of handgrip strength in the group that received alfacalcidol compared with the placebo group (15.50 vs 13.75; P = 0.003). The median time for the Timed-Up and Go test in the alfacalcidol group also improved significantly compared with the placebo group (9.01 vs 10.07, P = 0.028). CONCLUSIONS:Alfacalcidol with daily doses of 0.5 μg significantly improved muscle strength and functional mobility in Indonesian older women. Geriatr Gerontol Int 2018; 18: 434-440.
Authors: Farhad Pazan; Mirko Petrovic; Antonio Cherubini; Graziano Onder; Alfonso J Cruz-Jentoft; Michael Denkinger; Tischa J M van der Cammen; Jennifer M Stevenson; Kinda Ibrahim; Chakravarthi Rajkumar; Marit Stordal Bakken; Jean-Pierre Baeyens; Peter Crome; Thomas Frühwald; Paul Gallaghar; Adalsteinn Guðmundsson; Wilma Knol; Denis O'Mahony; Alberto Pilotto; Elina Rönnemaa; José Antonio Serra-Rexach; George Soulis; Rob J van Marum; Gijsbertus Ziere; Alpana Mair; Heinrich Burkhardt; Agnieszka Neumann-Podczaska; Katarzyna Wieczorowska-Tobis; Marilia Andreia Fernandes; Heidi Gruner; Dhayana Dallmeier; Jean-Baptiste Beuscart; Nathalie van der Velde; Martin Wehling Journal: Eur J Clin Pharmacol Date: 2020-08-07 Impact factor: 2.953