Tracy Glass1, Mohamed A Dalvie1, Zelda Holtman1, Anna A Vorster2, Rajkumar S Ramesar2, Leslie London1. 1. School of Public Health and Family Medicine, University of Cape Town, Centre for Environmental and Occupational Health Research (CEOHR), Cape Town, Western Cape, South Africa. 2. MRC Human Genetics Research Unit, Division of Human Genetics, Institute for Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Abstract
BACKGROUND: Previous epidemiological studies investigating modification of organophosphate (OP) neurotoxicity by xenobiotic metabolizing enzymes (XMEs) polymorphisms have produced inconsistent results. METHODS: A cross-sectional study of 301 emerging farmers was conducted. Neurotoxicity testing included forward and backward recall, digit span, and vibration sensitivity testing. Questionnaire data included demography, potential confounders, and work history of pesticide exposures. Genomic DNA was analyzed from study participants for DNA variants of two glutathione S-transferases (GSTM1 and GSTT1), N-acetyltransferase 2 (NAT2), and Paraoxonase 1 (PON1). RESULTS: There was evidence of OP pesticide neurotoxicity modification by rs1799931 (NAT2), rs662 (PON1), and the null allele of GSTM1 in multivariate analysis. The strongest evidence of modification was observed for rs1799931 (NAT2) on the relationship between pesticide poisoning and impaired vibration sense. CONCLUSIONS: DNA variants of NAT2, PON1, and GSTM1 may modify OP neurotoxicity, and this requires further exploration.
BACKGROUND: Previous epidemiological studies investigating modification of organophosphate (OP) neurotoxicity by xenobiotic metabolizing enzymes (XMEs) polymorphisms have produced inconsistent results. METHODS: A cross-sectional study of 301 emerging farmers was conducted. Neurotoxicity testing included forward and backward recall, digit span, and vibration sensitivity testing. Questionnaire data included demography, potential confounders, and work history of pesticide exposures. Genomic DNA was analyzed from study participants for DNA variants of two glutathione S-transferases (GSTM1 and GSTT1), N-acetyltransferase 2 (NAT2), and Paraoxonase 1 (PON1). RESULTS: There was evidence of OP pesticide neurotoxicity modification by rs1799931 (NAT2), rs662 (PON1), and the null allele of GSTM1 in multivariate analysis. The strongest evidence of modification was observed for rs1799931 (NAT2) on the relationship between pesticide poisoning and impaired vibration sense. CONCLUSIONS: DNA variants of NAT2, PON1, and GSTM1 may modify OP neurotoxicity, and this requires further exploration.
Authors: Martin Röösli; Samuel Fuhrimann; Aggrey Atuhaire; Hanna-Andrea Rother; James Dabrowski; Brenda Eskenazi; Erik Jørs; Paul C Jepson; Leslie London; Saloshni Naidoo; Diane S Rohlman; Ivy Saunyama; Berna van Wendel de Joode; Adeoluwa O Adeleye; Oyebanji O Alagbo; Dem Aliaj; Jember Azanaw; Ravichandran Beerappa; Curdin Brugger; Sunisa Chaiklieng; Shala Chetty-Mhlanga; Grace A Chitra; Venugopal Dhananjayan; Afure Ejomah; Christian Ebere Enyoh; Yamdeu Joseph Hubert Galani; Jonathan N Hogarh; Janefrances N Ihedioha; Jeanne Priscille Ingabire; Ellinor Isgren; Yêyinou Laura Estelle Loko; Liana Maree; Nkoum Metou'ou Ernest; Haruna Musa Moda; Edward Mubiru; Mwema Felix Mwema; Immaculate Ndagire; Godwin O Olutona; Peter Otieno; Jordan M Paguirigan; Reginald Quansah; Charles Ssemugabo; Seruwo Solomon; Mosudi B Sosan; Mohammad Bashir Sulaiman; Berhan M Teklu; Isioma Tongo; Osariyekemwen Uyi; Henry Cueva-Vásquez; Adriana Veludo; Paola Viglietti; Mohamed Aqiel Dalvie Journal: Int J Environ Res Public Health Date: 2022-07-23 Impact factor: 4.614
Authors: Emily Terese Sturm; Colton Castro; Andrea Mendez-Colmenares; John Duffy; Agnieszka Aga Z Burzynska; Lorann Stallones; Michael L Thomas Journal: Int J Environ Res Public Health Date: 2022-03-13 Impact factor: 3.390