Literature DB >> 29143019

Half-sandwich ruthenium(ii) complexes containing N^N-chelated imino-pyridyl ligands that are selectively toxic to cancer cells.

Meng Tian1, Juanjuan Li, Shumiao Zhang, Lihua Guo, Xiangdong He, Deliang Kong, Hairong Zhang, Zhe Liu.   

Abstract

Chemotherapy is limited by its poor selectivity towards cancer cells over normal cells. Herein, we designed half-sandwich ruthenium imino-pyridyl complexes [(η6-bz)Ru(N^N)Cl]PF6 to achieve selective cytotoxicity to cancer cells. This kind of ruthenium complex has unique characteristics and is worthy of further exploration in the design of new anticancer drugs.

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Year:  2017        PMID： 29143019     DOI： 10.1039/c7cc08270c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  6 in total

1.  The Synthesis, Characterization, Molecular Docking and In Vitro Antitumor Activity of Benzothiazole Aniline (BTA) Conjugated Metal-Salen Complexes as Non-Platinum Chemotherapeutic Agents.

Authors:  Md Kamrul Islam; Seongmin Ha; Ah-Rum Baek; Byeong-Woo Yang; Yeoun-Hee Kim; Hyun-Jin Park; Minsup Kim; Sung-Wook Nam; Gang-Ho Lee; Yongmin Chang
Journal:  Pharmaceuticals (Basel)       Date:  2022-06-15

2.  Novel iridium(III) iminopyridine complexes: synthetic, catalytic, and in vitro anticancer activity studies.

Authors:  Deliang Kong; Meng Tian; Lihua Guo; Xicheng Liu; Shumiao Zhang; Yameng Song; Xin Meng; Shu Wu; Lingzi Zhang; Zhe Liu
Journal:  J Biol Inorg Chem       Date:  2018-06-11       Impact factor: 3.358

3.  Oxamusplatin: a cytotoxic Pt(ii) complex of a nitrogen mustard with resistance to thiol based sequestration displays enhanced selectivity towards cancer.

Authors:  Moumita Maji; Subhendu Karmakar; Arnab Gupta; Arindam Mukherjee
Journal:  Dalton Trans       Date:  2020-02-25       Impact factor: 4.390

4.  Organoaluminum Compounds as Catalysts for Monohydroboration of Carbodiimides.

Authors:  Qiumiao Shen; Xiaoli Ma; Wenling Li; Wenqing Liu; Yi Ding; Zhi Yang; Herbert W Roesky
Journal:  Chemistry       Date:  2019-08-13       Impact factor: 5.236

5.  New Cationic fac-[Re(CO)3(deeb)B2]+ Complex, Where B2 Is a Benzimidazole Derivative, as a Potential New Luminescent Dye for Proteins Separated by SDS-PAGE.

Authors:  Alexander Carreño; Manuel Gacitúa; Eduardo Solis-Céspedes; Dayán Páez-Hernández; Wesley B Swords; Gerald J Meyer; Marcelo D Preite; Ivonne Chávez; Andrés Vega; Juan A Fuentes
Journal:  Front Chem       Date:  2021-03-25       Impact factor: 5.221

Review 6.  Metal Complexes or Chelators with ROS Regulation Capacity: Promising Candidates for Cancer Treatment.

Authors:  Xiang Li; Yuhui Wang; Man Li; Huipeng Wang; Xiongwei Dong
Journal:  Molecules       Date:  2021-12-27       Impact factor: 4.411
  6 in total

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