Literature DB >> 29142009

Dominant negative mechanism of Presenilin-1 mutations in FAD.

Hirotaka Watanabe1, Jie Shen2.   

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Year:  2017        PMID： 29142009      PMCID： PMC5715794          DOI： 10.1073/pnas.1717180114

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


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  20 in total

1.  Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1.

Authors:  K Duff; C Eckman; C Zehr; X Yu; C M Prada; J Perez-tur; M Hutton; L Buee; Y Harigaya; D Yager; D Morgan; M N Gordon; L Holcomb; L Refolo; B Zenk; J Hardy; S Younkin
Journal:  Nature       Date:  1996-10-24       Impact factor: 49.962

Review 2.  The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism.

Authors:  Jie Shen; Raymond J Kelleher
Journal:  Proc Natl Acad Sci U S A       Date:  2006-12-29       Impact factor: 11.205

3.  Assessment of normal and mutant human presenilin function in Caenorhabditis elegans.

Authors:  D Levitan; T G Doyle; D Brousseau; M K Lee; G Thinakaran; H H Slunt; S S Sisodia; I Greenwald
Journal:  Proc Natl Acad Sci U S A       Date:  1996-12-10       Impact factor: 11.205

4.  Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex.

Authors:  Geneviève Evin; Louise D Canterford; David E Hoke; Robyn A Sharples; Janetta G Culvenor; Colin L Masters
Journal:  Biochemistry       Date:  2005-03-22       Impact factor: 3.162

5.  A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity.

Authors:  Elizabeth A Heilig; Weiming Xia; Jie Shen; Raymond J Kelleher
Journal:  J Biol Chem       Date:  2010-05-11       Impact factor: 5.157

6.  Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase.

Authors:  Linfeng Sun; Rui Zhou; Guanghui Yang; Yigong Shi
Journal:  Proc Natl Acad Sci U S A       Date:  2016-12-05       Impact factor: 11.205

7.  Modeling clinically heterogeneous presenilin mutations with transgenic Drosophila.

Authors:  Glen A Seidner; Yihong Ye; Martha M Faraday; W Gregory Alvord; Mark E Fortini
Journal:  Curr Biol       Date:  2006-05-23       Impact factor: 10.834

8.  Trans-dominant negative effects of pathogenic PSEN1 mutations on γ-secretase activity and Aβ production.

Authors:  Elizabeth A Heilig; Usha Gutti; Tara Tai; Jie Shen; Raymond J Kelleher
Journal:  J Neurosci       Date:  2013-07-10       Impact factor: 6.167

9.  Loss of Aβ43 Production Caused by Presenilin-1 Mutations in the Knockin Mouse Brain.

Authors:  Dan Xia; Raymond J Kelleher; Jie Shen
Journal:  Neuron       Date:  2016-04-20       Impact factor: 17.173

10.  Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization.

Authors:  Rui Zhou; Guanghui Yang; Yigong Shi
Journal:  Proc Natl Acad Sci U S A       Date:  2017-10-09       Impact factor: 11.205
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  6 in total

1.  Presenilin Is Essential for ApoE Secretion, a Novel Role of Presenilin Involved in Alzheimer's Disease Pathogenesis.

Authors:  Sadequl Islam; Yang Sun; Yuan Gao; Tomohisa Nakamura; Arshad Ali Noorani; Tong Li; Philip C Wong; Noriyuki Kimura; Etsuro Matsubara; Kensaku Kasuga; Takeshi Ikeuchi; Taisuke Tomita; Kun Zou; Makoto Michikawa
Journal:  J Neurosci       Date:  2022-01-05       Impact factor: 6.709

2.  Evolutionary History of Alzheimer Disease-Causing Protein Family Presenilins with Pathological Implications.

Authors:  Ammad Aslam Khan; Raja Hashim Ali; Bushra Mirza
Journal:  J Mol Evol       Date:  2020-10-01       Impact factor: 2.395

Review 3.  Notch3 Signaling and Aggregation as Targets for the Treatment of CADASIL and Other NOTCH3-Associated Small-Vessel Diseases.

Authors:  Dorothee Schoemaker; Joseph F Arboleda-Velasquez
Journal:  Am J Pathol       Date:  2021-04-22       Impact factor: 4.307

4.  Flexible and Accurate Substrate Processing with Distinct Presenilin/γ-Secretases in Human Cortical Neurons.

Authors:  Hirotaka Watanabe; Kent Imaizumi; Tetsuo Cai; Zhi Zhou; Taisuke Tomita; Hideyuki Okano
Journal:  eNeuro       Date:  2021-03-03

Review 5.  Emerging Electroencephalographic Biomarkers to Improve Preclinical to Clinical Translation in Alzheimer's Disease.

Authors:  Zackary A Cope; Takeshi Murai; Stacey J Sukoff Rizzo
Journal:  Front Aging Neurosci       Date:  2022-02-17       Impact factor: 5.750

6.  Presenilin Deficiency Increases Susceptibility to Oxidative Damage in Fibroblasts.

Authors:  Kun Zou; Sadequl Islam; Yang Sun; Yuan Gao; Tomohisa Nakamura; Hiroto Komano; Taisuke Tomita; Makoto Michikawa
Journal:  Front Aging Neurosci       Date:  2022-06-16       Impact factor: 5.702
  6 in total

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