| Literature DB >> 29141636 |
Oliver Schnell1, Lars Rydén2, Eberhard Standl3, Antonio Ceriello4,5.
Abstract
Following publication of the original article [1], the authors submitted a corrected version of Table 4 (see below).Entities:
Year: 2017 PMID: 29141636 PMCID: PMC5686894 DOI: 10.1186/s12933-017-0633-4
Source DB: PubMed Journal: Cardiovasc Diabetol ISSN: 1475-2840 Impact factor: 9.951
Comparison of outcome results from terminated CVOTs in comparison to placebo
| SAVOR-TIMI53 [1, 2] | EXAMINE [3, 4] | TECOS [5] | ELIXA [6] | EMPA-REG OUTCOME [7] | LEADER [8] | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Class | HR (95% CI) | Class | HR (95% CI) | Class | HR (95% CI) | Class | HR (95% CI) | Class | HR (95% CI) | Class | HR (95% CI) | |
| p value | p value | p value | p value | p value | p value | |||||||
| Cardiovascular endpoints | ||||||||||||
| Primary composite MACE | CV death, MI, or stroke | 1.00 (0.89–1.12) | CV death, MI, or stroke | 0.96 (≤ 1.16) | CV death, MI, UA, or stroke | 0.98 (0.89–1.08) | CV death, MI, UA, or stroke | 1.02 (0.89–1.17) | CV death, MI, or stroke | 0.86 (0.74–0.99) | CV death, MI, or stroke | 0.87 (0.78–0.97) |
| Cardiovascular death | Primary endpoint | 1.03 (0.87–1.22) | Primary endpoint | 0.79 (0.60–1.04) | Secondary endpoint | 1.03 (0.89–1.19) | Primary endpoint | 0.98 (0.78–1.22) | Primary endpoint | 0.62 (0.49–0.77) | Primary endpoint | 0.78 (0.66–0.93) |
| Myocardial infarction | Primary endpoint | 0.95 (0.80–1.12) | Primary endpoint | 1.08 (0.88–1.33) | Secondary endpoint | 0.95 (0.81–1.11) | Primary endpoint | 1.03 (0.87–1.22) | Primary endpoint | 0.87 (0.70–1.09) | Primary endpoint | 0.86 (0.73–1.00) |
| Stroke | Primary endpoint | 1.11 (0.88–1.39) | Primary endpoint | 0.91 (0.55–1.50) | Secondary endpoint | 0.97 (0.79–1.19) | Primary endpoint | 1.12 (0.79–1.58) | Primary endpoint | 1.18 (0.89–1.56) | Primary endpoint | 0.86 (0.71–1.06) |
| Hospitalization for unstable angina | Secondary endpoint | 1.19 (0.89–1.60) | Secondary endpoint | 0.90 (0.60–1.37) | Secondary endpoint | 0.90 (0.70–1.16) | Primary endpoint | 1.11 (0.47–2.62) | Secondary endpoint | 0.99 (0.74–1.34) | Extended | 0.98 (0.76–1.26) |
| Hospitalization for heart failure | Secondary endpoint | 1.27 (1.07–1.51) | Extended primary endpoint | 1.19 (0.90–1.58) | Secondary endpoint | 1.00 (0.83–1.20) | Secondary endpoint | 0.96 (0.75–1.23) | Secondary endpoint | 0.65 (0.50–0.85) | Extended | 0.87 (0.73–1.05) |
aSuperiority test
bAverage across all age ranges
cSevere hypoglycaemia as defined by ADA
dNumber of participants per 1000 patient-years