Literature DB >> 29141636

Correction to: Updates on cardiovascular outcome trials in diabetes.

Oliver Schnell1, Lars Rydén2, Eberhard Standl3, Antonio Ceriello4,5.   

Abstract

Following publication of the original article [1], the authors submitted a corrected version of Table 4 (see below).

Entities:  

Year:  2017        PMID: 29141636      PMCID: PMC5686894          DOI: 10.1186/s12933-017-0633-4

Source DB:  PubMed          Journal:  Cardiovasc Diabetol        ISSN: 1475-2840            Impact factor:   9.951


Correction to: Cardiovasc Diabetol (2017) 16:128 10.1186/s12933-017-0610-y

Following publication of the original article [1], the authors submitted a corrected version of Table 4 (see below), as the original version contained a mistake.
Table 4

Comparison of outcome results from terminated CVOTs in comparison to placebo

SAVOR-TIMI53 [1, 2]EXAMINE [3, 4]TECOS [5]ELIXA [6]EMPA-REG OUTCOME [7]LEADER [8]
ClassHR (95% CI)ClassHR (95% CI)ClassHR (95% CI)ClassHR (95% CI)ClassHR (95% CI)ClassHR (95% CI)
p valuep valuep valuep valuep valuep value
Cardiovascular endpoints
 Primary composite MACECV death, MI, or stroke1.00 (0.89–1.12)0.99CV death, MI, or stroke0.96 (≤ 1.16)0.32CV death, MI, UA, or stroke0.98 (0.89–1.08)0.65CV death, MI, UA, or stroke1.02 (0.89–1.17)0.81CV death, MI, or stroke0.86 (0.74–0.99)0.04a CV death, MI, or stroke0.87 (0.78–0.97)0.01
 Cardiovascular deathPrimary endpoint1.03 (0.87–1.22)0.72Primary endpoint0.79 (0.60–1.04)0.10Secondary endpoint1.03 (0.89–1.19)0.71Primary endpoint0.98 (0.78–1.22)0.85Primary endpoint0.62 (0.49–0.77)< 0.001Primary endpoint0.78 (0.66–0.93)0.007
 Myocardial infarctionPrimary endpoint0.95 (0.80–1.12)0.52Primary endpoint1.08 (0.88–1.33)0.47Secondary endpoint0.95 (0.81–1.11)0.49Primary endpoint1.03 (0.87–1.22)0.71Primary endpoint0.87 (0.70–1.09)0.23Primary endpoint0.86 (0.73–1.00)0.046
 StrokePrimary endpoint1.11 (0.88–1.39)0.38Primary endpoint0.91 (0.55–1.50)0.71Secondary endpoint0.97 (0.79–1.19)0.76Primary endpoint1.12 (0.79–1.58)0.54Primary endpoint1.18 (0.89–1.56)0.26Primary endpoint0.86 (0.71–1.06)0.16
 Hospitalization for unstable anginaSecondary endpoint1.19 (0.89–1.60)0.24Secondary endpoint0.90 (0.60–1.37)0.632Secondary endpoint0.90 (0.70–1.16)0.42Primary endpoint1.11 (0.47–2.62)0.81Secondary endpoint0.99 (0.74–1.34)0.97Extendedprimary endpoint0.98 (0.76–1.26)0.87
 Hospitalization for heart failureSecondary endpoint1.27 (1.07–1.51)0.007Extended primary endpoint1.19 (0.90–1.58)0.220Secondary endpoint1.00 (0.83–1.20)0.98Secondary endpoint0.96 (0.75–1.23)0.75Secondary endpoint0.65 (0.50–0.85)0.002Extendedprimary endpoint0.87 (0.73–1.05)0.14

aSuperiority test

bAverage across all age ranges

cSevere hypoglycaemia as defined by ADA

dNumber of participants per 1000 patient-years

Comparison of outcome results from terminated CVOTs in comparison to placebo aSuperiority test bAverage across all age ranges cSevere hypoglycaemia as defined by ADA dNumber of participants per 1000 patient-years The original article has been corrected. References Leiter LA, et al. Efficacy and safety of saxagliptin in older participants in the SAVOR-TIMI 53 trial. Diabetes Care. 2015;38(6):1145–53. Scirica BM, et al. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med. 2013;369(14):1317–26. White WB, et al. Alogliptin after acute coronary syndrome in patients with type 2 diabetes. N Engl J Med. 2013;369(14):1327–35. Zannad F, et al. Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE: a multicentre, randomised, double-blind trial. Lancet. 2015;385(9982):2067–76. Green JB, et al. Effect of sitagliptin on cardiovascular outcomes in Type 2 diabetes. N Engl J Med. 2015;373(3):232–42. Pfeffer MA, et al. Lixisenatide in patients with Type 2 diabetes and acute coronary syndrome. N Engl J Med. 2015;373(23):2247–57. Zinman B, et al. Empagliflozin, cardiovascular outcomes, and mortality in Type 2 diabetes. N Engl J Med. 2015;373(22):2117–28. Marso SP, et al. Liraglutide and cardiovascular outcomes in Type 2 diabetes. N Engl J Med. 2016;375(4):311–22 Marso SP, et al. Semaglutide and cardiovascular outcomes in patients with Type 2 diabetes. N Engl J Med. 2016;375(19):1834–44. Holman RR, et al. Effects of once-weekly exenatide on cardiovascular outcomes in Type 2 diabetes. N Engl J Med. 2017;377(13):1228–39. Marso SP, et al. Efficacy and safety of degludec versus glargine in Type 2 diabetes. N Engl J Med. 2017;377(8):723–32. Neal B, et al. Canagliflozin and cardiovascular and renal events in Type 2 diabetes. N Engl J Med. 2017;377(7):644-57. Holman RR, et al. Effects of acarbose on cardiovascular and diabetes outcomes in patients with coronary heart disease and impaired glucose tolerance (ACE): a randomised, double-blind, placebo-controlled trial. Lancet Diabetes Endocrinol. 2017;S2213-8587(17):30309–1.
  1 in total

Review 1.  Updates on cardiovascular outcome trials in diabetes.

Authors:  Oliver Schnell; Lars Rydén; Eberhard Standl; Antonio Ceriello
Journal:  Cardiovasc Diabetol       Date:  2017-10-11       Impact factor: 9.951

  1 in total

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