Abolfazl Shakeri 1 , Mohammad Reza Zirak 2 , Amirhossein Sahebkar 3,4 Show Affiliations »
Abstract
BACKGROUND: Naturally occurring polyphenols are the subject of increasing attention due to their potent antioxidant activity and their marked effects on the prevention of various oxidative stress-associated diseases such as cancer. Ellagic acid (EA) is an herbal polyphenol that is structurally a condensed dimer of gallic acid. METHODS: This review aims to provide a comprehensive and updated overview on the biological activities of EA and potential therapeutic applications. RESULTS: EA is found in fruits and nuts, either in the combined form with hexahydroxydiphenic acid or in the bound form (ellagitannins). EA exhibits many biological properties such as antioxidant, anti-diabetic, anticancer and apoptosis-inducing activities. These biological and pharmacological properties are relevant to the treatment of several human diseases. CONCLUSION: Owing to its multiple mechanisms of action, EA represents a potential therapeutic agent against human diseases particularly cancer. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
BACKGROUND: Naturally occurring polyphenols are the subject of increasing attention due to their potent antioxidant activity and their marked effects on the prevention of various oxidative stress-associated diseases such as cancer . Ellagic acid (EA ) is an herbal polyphenol that is structurally a condensed dimer of gallic acid . METHODS: This review aims to provide a comprehensive and updated overview on the biological activities of EA and potential therapeutic applications. RESULTS: EA is found in fruits and nuts, either in the combined form with hexahydroxydiphenic acid or in the bound form (ellagitannins ). EA exhibits many biological properties such as antioxidant, anti-diabetic , anticancer and apoptosis-inducing activities. These biological and pharmacological properties are relevant to the treatment of several human diseases. CONCLUSION: Owing to its multiple mechanisms of action, EA represents a potential therapeutic agent against human diseases particularly cancer . Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Entities: Chemical
Disease
Species
Keywords:
Polyphenol; antioxidant; ellagic acid; gallic acid; pharmacology; phytomedicine.
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Year: 2018
PMID： 29141541 DOI： 10.2174/1381612823666171115094557
Source DB: PubMed Journal: Curr Pharm Des ISSN： 1381-6128 Impact factor: 3.116