Literature DB >> 29140403

KLHL6 Is Preferentially Expressed in Germinal Center-Derived B-Cell Lymphomas.

Christian A Kunder1, Giovanna Roncador2, Ranjana H Advani3, Gabriela Gualco4, Carlos E Bacchi4, Jean M Sabile3, Izidore S Lossos5, Kexin Nie6,7, Robert John Tibshirani6,7, Michael R Green3,8, Ash A Alizadeh3, Yasodha Natkunam1.   

Abstract

OBJECTIVES: KLHL6 is a recently described BTB-Kelch protein with selective expression in lymphoid tissues and is most strongly expressed in germinal center B cells.
METHODS: Using gene expression profiling as well as immunohistochemistry with an anti-KLHL6 monoclonal antibody, we have characterized the expression of this molecule in normal and neoplastic tissues. Protein expression was evaluated in 1,058 hematopoietic neoplasms.
RESULTS: Consistent with its discovery as a germinal center marker, KLHL6 was positive mainly in B-cell neoplasms of germinal center derivation, including 95% of follicular lymphomas (106/112). B-cell lymphomas of non-germinal center derivation were generally negative (0/33 chronic lymphocytic leukemias/small lymphocytic lymphomas, 3/49 marginal zone lymphomas, and 2/66 mantle cell lymphomas).
CONCLUSIONS: In addition to other germinal center markers, including BCL6, CD10, HGAL, and LMO2, KLHL6 immunohistochemistry may prove a useful adjunct in the diagnosis and future classification of B-cell lymphomas. © American Society for Clinical Pathology, 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

Entities:  

Keywords:  Hematopathology; Immunohistochemistry; KLHL6; Lymphoma

Mesh：

Substances：

Year:  2017        PMID： 29140403      PMCID： PMC6279122          DOI： 10.1093/ajcp/aqx099

Source DB:  PubMed          Journal:  Am J Clin Pathol        ISSN： 0002-9173            Impact factor:   2.493


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