Jakob Lüker1, Arian Sultan2, Tobias Plenge2, Samuel Lee2, Jan-Hendrik van den Bruck2, Daniel Steven2. 1. Department of Electrophysiology, University Hospital Cologne, Kerpener Straße 62, 50823, Cologne, Germany. jakob.lueker@uk-koeln.de. 2. Department of Electrophysiology, University Hospital Cologne, Kerpener Straße 62, 50823, Cologne, Germany.
Abstract
BACKGROUND: Propofol is one of the most commonly used intravenous anaesthetic drugs for surgical procedures. The use of propofol for sedation is also common practice during endoscopic procedures, electrophysiology studies, and ablation procedures, as well as pacemaker and defibrillator implantation. It was found that propofol alters the electrophysiologic properties of the heart and its conduction system. The effects of propofol on pacing thresholds are unknown and could have implications for pacemaker (PM) and defibrillator (ICD) implantation procedures, as well as sedation and anaesthesia in PM and ICD patients in general. OBJECTIVES: We sought to investigate the effects of propofol sedation on atrial and right ventricular pacing thresholds in PM and ICD patients. MATERIALS AND METHODS: A total of 50 patients with PM, ICD, or cardiac resynchronization therapy (CRT) undergoing propofol sedation for electrophysiology (EP) investigation, transesophageal echocardiography (TEE), electrocardioversion (ECV), or bronchoscopy were included prospectively. Pacing thresholds, impedance, and sensing were assessed by device interrogation immediately prior to sedation and after the desired sedation depth was achieved by the administration of propofol. RESULTS: Mean atrial (0.68 V vs 0.77 V, p = 0.136) and mean right ventricular thresholds (0.90 V vs 0.93 V, p = 0.274) remained unchanged. Impedances and sensing remained unaffected in all patients. CONCLUSIONS: Propofol sedation did not affect pacing thresholds of atrial and right ventricular leads in this cohort of PM and ICD patients.
BACKGROUND:Propofol is one of the most commonly used intravenous anaesthetic drugs for surgical procedures. The use of propofol for sedation is also common practice during endoscopic procedures, electrophysiology studies, and ablation procedures, as well as pacemaker and defibrillator implantation. It was found that propofol alters the electrophysiologic properties of the heart and its conduction system. The effects of propofol on pacing thresholds are unknown and could have implications for pacemaker (PM) and defibrillator (ICD) implantation procedures, as well as sedation and anaesthesia in PM and ICDpatients in general. OBJECTIVES: We sought to investigate the effects of propofol sedation on atrial and right ventricular pacing thresholds in PM and ICDpatients. MATERIALS AND METHODS: A total of 50 patients with PM, ICD, or cardiac resynchronization therapy (CRT) undergoing propofol sedation for electrophysiology (EP) investigation, transesophageal echocardiography (TEE), electrocardioversion (ECV), or bronchoscopy were included prospectively. Pacing thresholds, impedance, and sensing were assessed by device interrogation immediately prior to sedation and after the desired sedation depth was achieved by the administration of propofol. RESULTS: Mean atrial (0.68 V vs 0.77 V, p = 0.136) and mean right ventricular thresholds (0.90 V vs 0.93 V, p = 0.274) remained unchanged. Impedances and sensing remained unaffected in all patients. CONCLUSIONS:Propofol sedation did not affect pacing thresholds of atrial and right ventricular leads in this cohort of PM and ICDpatients.
Authors: Tushar Vilas Salukhe; Stephan Willems; Imke Drewitz; Daniel Steven; Boris A Hoffmann; Katrin Heitmann; Thomas Rostock Journal: Europace Date: 2011-10-23 Impact factor: 5.214
Authors: Alexander Wutzler; Martin Huemer; Leif-Hendrik Boldt; Abdul Shokor Parwani; Philipp Attanasio; Verena Tscholl; Wilhelm Haverkamp Journal: Europace Date: 2013-02-12 Impact factor: 5.214