Literature DB >> 29138057

Hidradenitis Suppurativa-Like Lesions Associated with Pharmacologic Inhibition of Gamma-Secretase.

Geraldine O'Sullivan Coyne1, Therese S Woodring2, Chyi-Chia R Lee3, Alice P Chen4, Heidi H Kong5.   

Abstract

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Year:  2017        PMID： 29138057      PMCID： PMC8108066          DOI： 10.1016/j.jid.2017.09.051

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   8.551


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  9 in total

1.  gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis.

Authors:  Yonghua Pan; Meei-Hua Lin; Xiaolin Tian; Hui-Teng Cheng; Thomas Gridley; Jie Shen; Raphael Kopan
Journal:  Dev Cell       Date:  2004-11       Impact factor: 12.270

2.  A phase 3 trial of semagacestat for treatment of Alzheimer's disease.

Authors:  Rachelle S Doody; Rema Raman; Martin Farlow; Takeshi Iwatsubo; Bruno Vellas; Steven Joffe; Karl Kieburtz; Feng He; Xiaoying Sun; Ronald G Thomas; Paul S Aisen; Eric Siemers; Gopalan Sethuraman; Richard Mohs
Journal:  N Engl J Med       Date:  2013-07-25       Impact factor: 91.245

3.  Comorbidities of hidradenitis suppurativa (acne inversa).

Authors:  Sabine Fimmel; Christos C Zouboulis
Journal:  Dermatoendocrinol       Date:  2010-01

4.  Safety profile of semagacestat, a gamma-secretase inhibitor: IDENTITY trial findings.

Authors:  David B Henley; Karen L Sundell; Gopalan Sethuraman; Sherie A Dowsett; Patrick C May
Journal:  Curr Med Res Opin       Date:  2014-07-14       Impact factor: 2.580

5.  A Phase I, dose-finding study in patients with advanced solid malignancies of the oral γ-secretase inhibitor PF-03084014.

Authors:  Wells A Messersmith; Geoffrey I Shapiro; James M Cleary; Antonio Jimeno; Arvind Dasari; Bo Huang; M Naveed Shaik; Rossano Cesari; Xianxian Zheng; Jennifer M Reynolds; Patricia A English; Karen R McLachlan; Kenneth A Kern; Patricia M LoRusso
Journal:  Clin Cancer Res       Date:  2014-09-17       Impact factor: 12.531

6.  Hidradenitis suppurativa: a disease of the absent sebaceous gland? Sebaceous gland number and volume are significantly reduced in uninvolved hair follicles from patients with hidradenitis suppurativa.

Authors:  S Kamp; A M Fiehn; K Stenderup; C Rosada; B Pakkenberg; K Kemp; T N Dam; G B Jemec
Journal:  Br J Dermatol       Date:  2011-05       Impact factor: 9.302

7.  Clinical Activity of the γ-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors (Aggressive Fibromatosis).

Authors:  Shivaani Kummar; Geraldine O'Sullivan Coyne; Khanh T Do; Baris Turkbey; Paul S Meltzer; Eric Polley; Peter L Choyke; Robert Meehan; Rasa Vilimas; Yvonne Horneffer; Lamin Juwara; Ann Lih; Amul Choudhary; Sandra A Mitchell; Lee J Helman; James H Doroshow; Alice P Chen
Journal:  J Clin Oncol       Date:  2017-03-28       Impact factor: 44.544

Review 8.  γ-Secretase mutations in hidradenitis suppurativa: new insights into disease pathogenesis.

Authors:  Andrew E Pink; Michael A Simpson; Nemesha Desai; Richard C Trembath; Jonathan N W Barker
Journal:  J Invest Dermatol       Date:  2012-10-25       Impact factor: 8.551

9.  What causes hidradenitis suppurativa?

Authors:  H Kurzen; I Kurokawa; G B E Jemec; L Emtestam; K Sellheyer; E J Giamarellos-Bourboulis; I Nagy; F G Bechara; K Sartorius; J Lapins; D Krahl; P Altmeyer; J Revuz; C C Zouboulis
Journal:  Exp Dermatol       Date:  2008-05       Impact factor: 3.960
  9 in total
  5 in total

1.  Inter-rater reliability of phenotypes and exploratory genotype-phenotype analysis in inherited hidradenitis suppurativa.

Authors:  J W Frew; J E Hawkes; M Sullivan-Whalen; P Gilleaudeau; J G Krueger
Journal:  Br J Dermatol       Date:  2019-04-19       Impact factor: 9.302

Review 2.  Hidradenitis suppurativa.

Authors:  Robert Sabat; Gregor B E Jemec; Łukasz Matusiak; Alexa B Kimball; Errol Prens; Kerstin Wolk
Journal:  Nat Rev Dis Primers       Date:  2020-03-12       Impact factor: 52.329

Review 3.  Insights from γ-Secretase: Functional Genetics of Hidradenitis Suppurativa.

Authors:  Gautham Vellaichamy; Peter Dimitrion; Li Zhou; David Ozog; Henry W Lim; Wilson Liao; Iltefat H Hamzavi; Qing-Sheng Mi
Journal:  J Invest Dermatol       Date:  2021-04-07       Impact factor: 7.590

Review 4.  Hidradenitis Suppurativa as a Potential Subtype of Autoinflammatory Keratinization Disease.

Authors:  Toshifumi Nomura
Journal:  Front Immunol       Date:  2020-05-20       Impact factor: 7.561

5.  Interpreting the spectrum of gamma-secretase complex missense variation in the context of hidradenitis suppurativa-An in-silico study.

Authors:  Dillon Mintoff; Nikolai P Pace; Isabella Borg
Journal:  Front Genet       Date:  2022-09-02       Impact factor: 4.772
  5 in total

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